Literature DB >> 7202674

The effects of sodium and amiloride on the motility of the caudal epididymal spermatozoa of the rat.

P Y Wong, W M Lee, A Y Tsang.   

Abstract

The forward motility of the rat caudal epididymal spermatozoa has been studied in different Na+ concentrations. When spermatozoa were suspended in a completely Na+-free solution, the forward motility suffered a progressive fall and after 3 h was completely suppressed. This effect was fully reversible on resuspending the spermatozoa in a solution containing Na+. Amiloride caused a fall in motility and the effect was similar to that of Na+ removal. The inhibition by amiloride of the motility was concentration dependent and the dose response curve showed an IC50-value of about 5 x 10(-5) M. The role of Na+ influx in the maintenance of sperm motility was discussed.

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Year:  1981        PMID： 7202674     DOI： 10.1007/bf01965575

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  9 in total

1.  EFFECT OF IONS ON THE METABOLISM OF EJACULATED AND EPIDIDYMAL RAM SPERMATOZOA.

Authors:  J C WALLACE; R G WALES
Journal:  J Reprod Fertil       Date:  1964-10

2.  Bovine sperm forward motility protein. Partial purification and characterization.

Authors:  T S Acott; D D Hoskins
Journal:  J Biol Chem       Date:  1978-10-10       Impact factor: 5.157

3.  Ionic effects on the motility of bull and chimpanzee spermatozoa.

Authors:  A V McGrady; L Nelson; M Ireland
Journal:  J Reprod Fertil       Date:  1974-09

4.  Effects of triamterene and amiloride on urinary acidification and potassium excretion in the rat.

Authors:  J P Guignard; G Peters
Journal:  Eur J Pharmacol       Date:  1970-05       Impact factor: 4.432

5.  Amiloride inhibition of ion transport in perfused excretory duct of rat submaxillary gland.

Authors:  L H Schneyer
Journal:  Am J Physiol       Date:  1970-10

6.  Inhibition by amiloride of sodium-dependent fluid reabsorption in the rat isolated caudal epididymis.

Authors:  P Y Wong; C H Yeung
Journal:  Br J Pharmacol       Date:  1976-12       Impact factor: 8.739

7.  In vivo sodium, potassium, and sperm concentrations in the rat epididymis.

Authors:  T T Turner; P K Hartmann; S S Howards
Journal:  Fertil Steril       Date:  1977-02       Impact factor: 7.329

8.  Micropuncture studies of the electrochemical aspects of fluid and electrolyte transport in individual seminiferous tubules, the epididymis and the vas deferens in rats.

Authors:  N Levine; D J Marsh
Journal:  J Physiol       Date:  1971-03       Impact factor: 5.182

9.  Absorptive and secretory functions of the perfused rat cauda epididymidis.

Authors:  P Y Wong; C H Yeung
Journal:  J Physiol       Date:  1978-02       Impact factor: 5.182
  9 in total

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