Literature DB >> 7202520

Nimodipine inhibits carbocyclic thromboxane-induced contractions of cerebral arteries.

R Towart, E Perzborn.   

Abstract

Carbocyclic thromboxane A2 (CTA2) constricted rabbit basilar and saphenous arteries. The contractions of the basilar artery, but not those of the saphenous artery, were potently inhibited by the calcium antagonist nimodipine. Selective inhibition of thromboxane-induced vasoconstriction of cerebral vessels may contribute to the beneficial actions of calcium antagonists in models of cerebral ischaemia or vasospasm.

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Year:  1981        PMID： 7202520     DOI： 10.1016/0014-2999(81)90417-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  13 in total

Review 1.  Vasodilators.

Authors:  T T Zsotér
Journal:  Can Med Assoc J       Date:  1983-09-01       Impact factor: 8.262

2.  Relaxation of carbocyclic thromboxane A2-induced contractions of isolated coronary arteries by nifedipine.

Authors:  R Towart; E Perzborn
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-02       Impact factor: 3.000

Review 3.  Nimodipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in cerebrovascular disease.

Authors:  M S Langley; E M Sorkin
Journal:  Drugs       Date:  1989-05       Impact factor: 9.546

4.  Reversal of cerebral arterial spasm by intrathecal administration of a calcium antagonist (nimodipine).

Authors:  B Voldby; O F Petersen; M Buhl; P Jakobsen; R Ostergaard
Journal:  Acta Neurochir (Wien)       Date:  1984       Impact factor: 2.216

5.  Nimodipine-induced changes in the distribution of carotid blood flow and cardiac output in pentobarbitone-anaesthetized pigs.

Authors:  D J Duncker; J Heiligers; E J Mylecharane; P R Saxena; P D Verdouw
Journal:  Br J Pharmacol       Date:  1986-09       Impact factor: 8.739

6.  The pathophysiology of cerebral vasospasm, and pharmacological approaches to its management.

Authors:  R Towart
Journal:  Acta Neurochir (Wien)       Date:  1982       Impact factor: 2.216

7.  Evaluation of the calcium-antagonist nimodipine for the prevention of vasospasm after aneurysmal subarachnoid haemorrhage. A prospective transcranial Doppler ultrasound study.

Authors:  R W Seiler; P Grolimund; H R Zurbruegg
Journal:  Acta Neurochir (Wien)       Date:  1987       Impact factor: 2.216

8.  Actions of the novel thromboxane A2 antagonists, ONO-1270 and ONO-3708, on smooth muscle cells of the guinea-pig basilar artery.

Authors:  M Fujioka; T Nagao; H Kuriyama
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-12       Impact factor: 3.000

9.  Protective effects of Lycium barbarum polysaccharide on neonatal rat primary cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion.

Authors:  Chen Rui; Li Yuxiang; Hao Yinju; Zhu Qingluan; Wu Yang; Zhao Qipeng; Wang Hao; Ma Lin; Liu Juan; Zhao Chengjun; Jiang Yuanxu; Wang Yanrong; Dai Xiuying; Zhang Wannian; Sun Tao; Yu Jianqiang
Journal:  J Mol Histol       Date:  2012-05-05       Impact factor: 2.611

10.  Nimodipine has no effect on the cerebral circulation in conscious pigs, despite an increase in cardiac output.

Authors:  W J van der Giessen; D J Duncker; P R Saxena; P D Verdouw
Journal:  Br J Pharmacol       Date:  1990-06       Impact factor: 8.739
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