Literature DB >> 7063050

Relaxation of carbocyclic thromboxane A2-induced contractions of isolated coronary arteries by nifedipine.

R Towart, E Perzborn.   

Abstract

+/- Carbocyclic thromboxane A2 (2.9 x 10(-7) mol/l) contracted isolated rings of cat coronary artery. These contractions could be partly inhibited by low concentrations of nifedipine (50% inhibitory concentration - IC50 = 6.8 x 10(-8) mol/l) and completely relaxed by papaverine. Relaxation of thromboxane-induced coronary spasm may contribute to the effectiveness of calcium antagonists in variant angina, which may be caused or exacerbated by thromboxane A2 release from platelets.

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Year:  1982        PMID： 7063050     DOI： 10.1007/bf00500488

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  17 in total

1.  Levels of cyclic AMP and electrical events during inhibition of contractile activity in vascular smooth muscle.

Authors:  B Ljung; O Isaksson; B Johansson
Journal:  Acta Physiol Scand       Date:  1975-06

2.  Reciprocal regulation of human platelet cAMP levels by thromboxane A2 and prostacyclin.

Authors:  R R Gorman; F A Fitzpatrick; O V Miller
Journal:  Adv Cyclic Nucleotide Res       Date:  1978

Review 3.  Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle.

Authors:  A Fleckenstein
Journal:  Annu Rev Pharmacol Toxicol       Date:  1977       Impact factor: 13.820

4.  Role of cyclic AMP and Ca ++ in mechanical and metabolic events in isometrically contracting vascular smooth muscle.

Authors:  R Andersson
Journal:  Acta Physiol Scand       Date:  1973-01

5.  Inhibition of cyclic-3',5'-nucleotide-phosphodiesterase as a possible mode of action of papaverine and similarly acting drugs.

Authors:  W R Kukovetz; G Pöch
Journal:  Naunyn Schmiedebergs Arch Pharmakol       Date:  1970

6.  Pharmacology of agents that affect calcium. Agonists and antagonists.

Authors:  D J Triggle; V C Swamy
Journal:  Chest       Date:  1980-07       Impact factor: 9.410

7.  Dissociation of vasoconstrictor and platelet aggregatory activities of thromboxane by carbocyclic thromboxane A2, a stable analog of thromboxane A2.

Authors:  A M Lefer; E F Smith; H Araki; J B Smith; D Aharony; D A Claremon; R L Magolda; K C Nicolaou
Journal:  Proc Natl Acad Sci U S A       Date:  1980-03       Impact factor: 11.205

8.  Nifedipine therapy for coronary-artery spasm. Experience in 127 patients.

Authors:  E Antman; J Muller; S Goldberg; R MacAlpin; M Rubenfire; B Tabatznik; C S Liang; F Heupler; S Achuff; N Reichek; E Geltman; N Z Kerin; R K Neff; E Braunwald
Journal:  N Engl J Med       Date:  1980-06-05       Impact factor: 91.245

9.  The selective inhibition of serotonin-induced contractions of rabbit cerebral vascular smooth muscle by calcium-antagonistic dihydropyridines. An investigation of the mechanism of action of nimodipine.

Authors:  R Towart
Journal:  Circ Res       Date:  1981-05       Impact factor: 17.367

10.  Nimodipine inhibits carbocyclic thromboxane-induced contractions of cerebral arteries.

Authors:  R Towart; E Perzborn
Journal:  Eur J Pharmacol       Date:  1981-01-16       Impact factor: 4.432
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  1 in total

1.  Responses of human, monkey and dog coronary arteries in vitro to carbocyclic thromboxane A2 and vasodilators.

Authors:  N Toda
Journal:  Br J Pharmacol       Date:  1984-10       Impact factor: 8.739
  1 in total

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