Literature DB >> 7199205

Biosynthesis and processing of a human precursor complement protein, pro-C3, in a hepatoma-derived cell line.

K M Morris, G Goldberger, H R Colten, D P Aden, B B Knowles.   

Abstract

A 180,000-dalton single-chain molecule (human pro-C3) is the precursor of the third component of human complement (C3), a disulfide-linked two-chain protein. The pro-C3 is converted by limited proteolysis to C3. The relationship between pro-C3 and C3 was established with the use of Hep G2, a cell line derived from a human hepatocellular carcinoma, which synthesizes at least 17 plasma proteins.

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Year:  1982        PMID： 7199205     DOI： 10.1126/science.7199205

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  20 in total

1.  Human complement component C3: cDNA coding sequence and derived primary structure.

Authors:  M H de Bruijn; G H Fey
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

2.  The third component of complement is transcribed and secreted by cultured human endothelial cells.

Authors:  H B Warren; P Pantazis; P F Davies
Journal:  Am J Pathol       Date:  1987-10       Impact factor: 4.307

Review 3.  Complement biosynthesis by mononuclear phagocytes.

Authors:  A R McPhaden; K Whaley
Journal:  Immunol Res       Date:  1993       Impact factor: 2.829

4.  Quantitative determination of complement components produced by purified hepatocytes.

Authors:  G Ramadori; H Rasokat; R Burger; K H Meyer Zum Büschenfelde; D Bitter-Suermann
Journal:  Clin Exp Immunol       Date:  1984-01       Impact factor: 4.330

5.  Identification and partial characterization of the secreted form of the fourth component of human complement: evidence that it is different from major plasma form.

Authors:  A C Chan; K R Mitchell; T W Munns; D R Karp; J P Atkinson
Journal:  Proc Natl Acad Sci U S A       Date:  1983-01       Impact factor: 11.205

6.  Intracellular C3 Protects Human Airway Epithelial Cells from Stress-associated Cell Death.

Authors:  Hrishikesh S Kulkarni; Michelle L Elvington; Yi-Chieh Perng; M Kathryn Liszewski; Derek E Byers; Christopher Farkouh; Roger D Yusen; Deborah J Lenschow; Steven L Brody; John P Atkinson
Journal:  Am J Respir Cell Mol Biol       Date:  2019-02       Impact factor: 6.914

7.  Platelet-activating factor (PAF) stimulates the production of PAF acetylhydrolase by the human hepatoma cell line, HepG2.

Authors:  K Satoh; T Imaizumi; Y Kawamura; H Yoshida; M Hiramoto; S Takamatsu; M Takamatsu
Journal:  J Clin Invest       Date:  1991-02       Impact factor: 14.808

8.  Distinct mechanisms of epithelial adhesion for Candida albicans and Candida tropicalis. Identification of the participating ligands and development of inhibitory peptides.

Authors:  C M Bendel; M K Hostetter
Journal:  J Clin Invest       Date:  1993-10       Impact factor: 14.808

9.  Long-term biosynthesis of complement component C3 and alpha-1 acid glycoprotein by adult rat hepatocytes in a co-culture system with an epithelial liver cell-type.

Authors:  J P Lebreton; M Daveau; M Hiron; M Fontaine; D Biou; D Gilbert; C Guguen-Guillouzo
Journal:  Biochem J       Date:  1986-04-15       Impact factor: 3.857

10.  Complement biosynthesis by the human hepatoma-derived cell line HepG2.

Authors:  K M Morris; D P Aden; B B Knowles; H R Colten
Journal:  J Clin Invest       Date:  1982-10       Impact factor: 14.808
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