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Literature DB >> 7197924

Cell-free conversion of isopenicillin N into deacetoxycephalosporin C by Cephalosporium acremonium mutant M-0198.

J E Baldwin, J W Keeping, P D Singh, C A Vallejo.

Abstract

In a cell-free system prepared by lysis of protoplasts of Cephalosporium acremonium mutant M-0198, isopenicillin N was converted into a penicillinase-resistant material that behaved like deacetoxycephalosporin C on high-pressure liquid chromatography analysis. This activity was found to be unstable to storage at -80 degrees C; 70-80% of the activity was lost after 1 day.

Entities: Chemical Species

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Year: 1981 PMID： 7197924 PMCID： PMC1162792 DOI： 10.1042/bj1940649

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

8 in total

1. Stimulation of the conversion of penicillin N to cephalosporin by ascorbic acid, alpha-ketoglutarate, and ferrous ions in cell-free extracts of strains of Cephalosporium acremonium.

Authors: D J Hook; L T Chang; R P Elander; R B Morin
Journal: Biochem Biophys Res Commun Date: 1979-03-15 Impact factor: 3.575

2. Cell-free ring expansion of penicillin N to deacetoxycephalosporin C by Cephalosporium acremonium CW-19 and its mutants.

Authors: M Yoshida; T Konomi; M Kohsaka; J E Baldwin; S Herchen; P Singh; N A Hunt; A L Demain
Journal: Proc Natl Acad Sci U S A Date: 1978-12 Impact factor: 11.205

3. Cell-free conversion of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine into an antibiotic with the properties of isopenicillin N in Cephalosporium acremonium.

Authors: T Konomi; S Herchen; J E Baldwin; M Yoshida; N A Hunt; A L Demain
Journal: Biochem J Date: 1979-11-15 Impact factor: 3.857

4. Biosynthesis of penicillin N and cephalosporin C. Antibiotic production and other features of the metabolism of Cephalosporium sp.

Authors: B Smith; S C Warren; G G Newton; E P Abraham
Journal: Biochem J Date: 1967-06 Impact factor: 3.857

5. Incorporation of 3H and 14C from (6 alpha-3H)penicillin N and (10-14C,6 alpha-3H) penicillin N into deacetoxycephalosporin C.

Authors: J E Baldwin; P D Singh; M Yoshida; Y Sawada; A L Demain
Journal: Biochem J Date: 1980-03-15 Impact factor: 3.857

6. Incorporation of 3H from delta-(L-alpha-amino (4,5-3H)adipyl)-L-cysteinyl-D-(4,4-3H)valine into isopenicillin N.

Authors: J O'Sullivan; R C Bleaney; J A Huddleston; E P Abraham
Journal: Biochem J Date: 1979-11-15 Impact factor: 3.857

7. Further studies on microbiological ring-expansion of penicillin N.

Authors: Y Sawada; N A Hunt; A L Demain
Journal: J Antibiot (Tokyo) Date: 1979-12 Impact factor: 2.649

8. Syntheses of penicillin N, [6 alpha-3H]penicillin N and [10-14C,6 alpha-3H]penicillin N.

Authors: J E Baldwin; S R Herchen; P D Singh
Journal: Biochem J Date: 1980-03-15 Impact factor: 3.857