Literature DB >> 7197923

Conversion of isopenicillin N into penicillin N in cell-free extracts of Cephalosporium acremonium.

G S Jayatilake, J A Huddleston, E P Abraham.   

Abstract

In a cell-free system prepared by osmotic lysis of protoplasts of Cephalosporium acremonium, isopenicillin N is converted into penicillin N. The epimerase activity of the system is labile.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 7197923      PMCID： PMC1162791          DOI： 10.1042/bj1940645

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  9 in total

1.  Purification and some properties of cephalosporin N, a new penicillin.

Authors:  E P ABRAHAM; G G NEWTON
Journal:  Biochem J       Date:  1954-09       Impact factor: 3.857

2.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

3.  Synthesis of tritium-labelled isopenicillin N, penicillin N and 6-aminopenicillanic acid.

Authors:  J J Usher; B Loder; E P Abraham
Journal:  Biochem J       Date:  1975-12       Impact factor: 3.857

4.  Cell-free conversion of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine into an antibiotic with the properties of isopenicillin N in Cephalosporium acremonium.

Authors:  T Konomi; S Herchen; J E Baldwin; M Yoshida; N A Hunt; A L Demain
Journal:  Biochem J       Date:  1979-11-15       Impact factor: 3.857

5.  Synthesis of delta-(alpha-aminoadipyl)cysteinylvaline and its role in penicillin biosynthesis.

Authors:  P A Fawcett; J J Usher; J A Huddleston; R C Bleaney; J J Nisbet; E P Abraham
Journal:  Biochem J       Date:  1976-09-01       Impact factor: 3.857

6.  Biosynthesis of penicillin N and cephalosporin C. Antibiotic production and other features of the metabolism of Cephalosporium sp.

Authors:  B Smith; S C Warren; G G Newton; E P Abraham
Journal:  Biochem J       Date:  1967-06       Impact factor: 3.857

7.  Incorporation of 3H and 14C from (6 alpha-3H)penicillin N and (10-14C,6 alpha-3H) penicillin N into deacetoxycephalosporin C.

Authors:  J E Baldwin; P D Singh; M Yoshida; Y Sawada; A L Demain
Journal:  Biochem J       Date:  1980-03-15       Impact factor: 3.857

8.  Incorporation of 3H from delta-(L-alpha-amino (4,5-3H)adipyl)-L-cysteinyl-D-(4,4-3H)valine into isopenicillin N.

Authors:  J O'Sullivan; R C Bleaney; J A Huddleston; E P Abraham
Journal:  Biochem J       Date:  1979-11-15       Impact factor: 3.857

9.  Separation, purification and properties of beta-lactamase I and beta-lactamase II from Bacillus cereus 569/H/9.

Authors:  R B Davies; E P Abraham
Journal:  Biochem J       Date:  1974-10       Impact factor: 3.857
  9 in total
  7 in total

1.  Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate.

Authors:  Alexandra J Long; Ian J Clifton; Peter L Roach; Jack E Baldwin; Christopher J Schofield; Peter J Rutledge
Journal:  Biochem J       Date:  2003-06-15       Impact factor: 3.857

2.  The beta-lactam biosynthesis genes for isopenicillin N epimerase and deacetoxycephalosporin C synthetase are expressed from a single transcript in Streptomyces clavuligerus.

Authors:  S Kovacevic; M B Tobin; J R Miller
Journal:  J Bacteriol       Date:  1990-07       Impact factor: 3.490

Review 3.  Molecular regulation of beta-lactam biosynthesis in filamentous fungi.

Authors:  A A Brakhage
Journal:  Microbiol Mol Biol Rev       Date:  1998-09       Impact factor: 11.056

4.  Stereochemistry of the incorporation of valine methyl groups into methylene groups in cephalosporin C.

Authors:  C P Pang; R L White; E P Abraham; D H Crout; M Lutstorf; P J Morgan; A E Derome
Journal:  Biochem J       Date:  1984-09-15       Impact factor: 3.857

5.  Purification and initial characterization of an enzyme with deacetoxycephalosporin C synthetase and hydroxylase activities.

Authors:  J E Baldwin; R M Adlington; J B Coates; M J Crabbe; N P Crouch; J W Keeping; G C Knight; C J Schofield; H H Ting; C A Vallejo
Journal:  Biochem J       Date:  1987-08-01       Impact factor: 3.857

Review 6.  Genes for beta-lactam antibiotic biosynthesis.

Authors:  J F Martín; S Gutiérrez
Journal:  Antonie Van Leeuwenhoek       Date:  1995       Impact factor: 2.271

Review 7.  Regulation and compartmentalization of β-lactam biosynthesis.

Authors:  Juan F Martín; Ricardo V Ullán; Carlos García-Estrada
Journal:  Microb Biotechnol       Date:  2009-05-31       Impact factor: 5.813
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.