Literature DB >> 7195875

Failure of chlorpromazine to inhibit fluid accumulation caused by Escherichia coli heat-stable enterotoxin in suckling mice.

T Takeda, T Honda, Y Takeda, T Miwatani.   

Abstract

We studied the effect of chlorpromazine on fluid accumulation caused by purified heat-stable enterotoxin (ST) from enterotoxigenic Escherichia coli in suckling mice. We found that chlorpromazine inactivated ST itself in vitro, but did not inhibit the activity of ST in the intestines.

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Year:  1981        PMID： 7195875      PMCID： PMC351470          DOI： 10.1128/iai.32.2.480-483.1981

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  12 in total

1.  Reversal of cyclic AMP-mediated intestinal secretion in mice by chlorpromazine.

Authors:  J Holmgren; S Lange; I Lönnroth
Journal:  Gastroenterology       Date:  1978-12       Impact factor: 22.682

2.  Role of cyclic GMP in the action of heat-stable enterotoxin of Escherichia coli.

Authors:  J M Hughes; F Murad; B Chang; R L Guerrant
Journal:  Nature       Date:  1978-02-23       Impact factor: 49.962

3.  Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine.

Authors:  M Field; L H Graf; W J Laird; P L Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

4.  Stimulation of adenyl cyclase by Escherichia coli enterotoxin.

Authors:  D J Evans; L C Chen; G T Curlin; D G Evans
Journal:  Nat New Biol       Date:  1972-04-05

5.  Stimulation of intestinal adenyl cyclase by cholera toxin.

Authors:  G W Sharp; S Hynie
Journal:  Nature       Date:  1971-01-22       Impact factor: 49.962

6.  Chlorpromazine reverses diarrhea in piglets caused by enterotoxigenic Escherichia coli.

Authors:  I Lönnroth; B Andrén; S Lange; K Martinsson; J Holmgren
Journal:  Infect Immun       Date:  1979-06       Impact factor: 3.441

7.  Chlorpromazine reduces fluid-loss in cholera.

Authors:  G H Rabbani; W B Greenough; J Holmgren; I Lönnroth
Journal:  Lancet       Date:  1979-02-24       Impact factor: 79.321

8.  Inhibition of hormone-sensitive adenyl cyclase by phenothiazines.

Authors:  J Wolff; A B Jones
Journal:  Proc Natl Acad Sci U S A       Date:  1970-02       Impact factor: 11.205

9.  Elevated concentration of adenosine 3':5'-cyclic monophosphate in intestinal mucosa after treatment with cholera toxin.

Authors:  D E Schafer; W D Lust; B Sircar; N D Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1970-10       Impact factor: 11.205

10.  Detection of cholera enterotoxin activity in suckling hamsters.

Authors:  T Takeda; Y Takeda; T Miwatani; N Ohtomo
Journal:  Infect Immun       Date:  1978-02       Impact factor: 3.441
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  1 in total

1.  Characterization of the mechanism of action of Escherichia coli heat-stable enterotoxin.

Authors:  L A Dreyfus; L Jaso-Friedmann; D C Robertson
Journal:  Infect Immun       Date:  1984-05       Impact factor: 3.441
  1 in total

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