[On the diuretic and saluretic activity of p-hydroxytriamterene and methoxytriamterene (author's transl)].

Applying i.v. the phase-I-metabolite of 2,4,7-triamino-6-phenylpteridine (triamterene), p-hydroxytriamterene, to rats, we found a strong natriuresis. This contradicts the investigation of a previous study which stated that p-hydroxytriamterene is essentially inactive. We think, these different results depend on the fact that probably oral application was employed without testing the absorption concerned.