Literature DB >> 24271468

Pharmacodynamics of basic triamterene derivatives.

H Priewer1, H Spahn, E Mutschler.   

Abstract

Triamterene derivatives with a basic side chain and with an additional hydroxyl group in their side chain (hydroxy bases) were investigated for their effects on urine volume and electrolyte excretion in male Wistar rats. All basic derivatives enhance urine volume and sodium excretion. The hydroxy bases show a stronger antikaliuretic effect than the unhydroxylated derivatives. In the group of hydroxy bases the influence of the substitution grade of nitrogen and the role of the pKa values are discussed in order to establish possible structure-activity relationships regarding the antikaliuretic effect.

Entities:  

Year:  1986        PMID： 24271468     DOI： 10.1023/A:1016393420082

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  10 in total

1.  Importance of guanidinium groups of blocking sodium channels in epithelia.

Authors:  A W Cuthbert
Journal:  Mol Pharmacol       Date:  1976-11       Impact factor: 4.436

2.  PHASE SOLUBILITY TECHNIQUE IN STUDYING THE FORMATION OF COMPLEX SALTS OF TRIAMTERENE.

Authors:  L W DITTERT; T HIGUCHI; D R REESE
Journal:  J Pharm Sci       Date:  1964-11       Impact factor: 3.534

3.  Effect of amiloride and some of its analogues of cation transport in isolated frog skin and thin lipid membranes.

Authors:  D J Benos; S A Simon; L J Mandel; P M Cala
Journal:  J Gen Physiol       Date:  1976-07       Impact factor: 4.086

4.  Dissociation of the natriuretic and antikaliuretic properties of triamterene derivatives by dose-response experiments.

Authors:  H Priewer; E Wolf; H Kraft; H Knauf; E Mutschler
Journal:  Pharm Res       Date:  1987-02       Impact factor: 4.200

5.  Rates of alkaline hydrolysis and muscarinic activity of some aminoacetates and their quaternary ammonium analogs.

Authors:  A K Cho; D J Jenden; S I Lamb
Journal:  J Med Chem       Date:  1972-04       Impact factor: 7.446

6.  [Structure- and conformation-activity relationships of heterocyclic acetylcholine analogues, XIV: Acetylcholine esterase and base-catalyzed hydrolysis of enantiomeric 3-acetoxyquinuclidines (author's transl)].

Authors:  G Lambrecht
Journal:  Arch Pharm (Weinheim)       Date:  1982-07       Impact factor: 3.751

7.  Triamterene urolithiasis: solubility, pk, effect on crystal formation, and matrix binding of triamterene and its metabolites.

Authors:  P G Werness; J H Bergert; L H Smith
Journal:  J Lab Clin Med       Date:  1982-02

8.  [On the diuretic and saluretic activity of p-hydroxytriamterene and methoxytriamterene (author's transl)].

Authors:  G Vollmer; E Mutschler; K D Völger
Journal:  Arzneimittelforschung       Date:  1981

9.  Pharmacodynamics and pharmacokinetics of the basic triamterene analogue dimethylaminohydroxypropoxytriamterene.

Authors:  H Priewer; H Kraft; E Mutschler
Journal:  Arzneimittelforschung       Date:  1985

10.  Blockage of gallbladder tight junction cation-selective channels by 2,4,6-triaminopyrimidinium (TAP).

Authors:  J H Moreno
Journal:  J Gen Physiol       Date:  1975-07       Impact factor: 4.086
  10 in total
  1 in total

1.  Dissociation of the natriuretic and antikaliuretic properties of triamterene derivatives by dose-response experiments.

Authors:  H Priewer; E Wolf; H Kraft; H Knauf; E Mutschler
Journal:  Pharm Res       Date:  1987-02       Impact factor: 4.200
  1 in total

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