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Literature DB >> 7193583

A constituent of khat leaves with amphetamine-like releasing properties.

Abstract

Khat leaves, which are widely abused as a stimulant, contain the alkaloid (--)-cathinone. The effect of this compound on the efflux of radioactivity from rabbit striatal tissue prelabelled with [3H]dopamine was examined. (--)-Cathinone enhanced the release of label, and was found to have a potency similar to that of (+)-amphetamine. The observation demonstrates that the khat alkaloid also has amphetamine-like effects at the cellular level.

Entities: Chemical Species

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Year: 1980 PMID： 7193583 DOI： 10.1016/0014-2999(80)90326-x

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

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Cited

8 in total

Review 1. Synthetic cathinones: chemical phylogeny, physiology, and neuropharmacology.

Authors: Louis J De Felice; Richard A Glennon; Sidney S Negus
Journal: Life Sci Date: 2013-11-11 Impact factor: 5.037

2. The puzzle of drug-induced conditioned taste aversion: comparative studies with cathinone and amphetamine.

Authors: A J Goudie; T Newton
Journal: Psychopharmacology (Berl) Date: 1985 Impact factor: 4.530

3. Mephedrone and methylenedioxypyrovalerone (MDPV), major constituents of "bath salts," produce opposite effects at the human dopamine transporter.

Authors: Krasnodara Cameron; Renata Kolanos; Rakesh Vekariya; Rakesh Verkariya; Louis De Felice; Richard A Glennon
Journal: Psychopharmacology (Berl) Date: 2013-01-31 Impact factor: 4.530

A constituent of khat leaves with amphetamine-like releasing properties.

Review 1. Synthetic cathinones: chemical phylogeny, physiology, and neuropharmacology.

2. The puzzle of drug-induced conditioned taste aversion: comparative studies with cathinone and amphetamine.

3. Mephedrone and methylenedioxypyrovalerone (MDPV), major constituents of "bath salts," produce opposite effects at the human dopamine transporter.

4. Discriminative stimulus properties of cocaine in pigeons.

5. Khat: an amphetamine-like plant material.

Review 6. Cognitive deficits and neurotoxicity induced by synthetic cathinones: is there a role for neuroinflammation?

Review 7. DARK Classics in Chemical Neuroscience: Cathinone-Derived Psychostimulants.

Review 8. An updated review on synthetic cathinones.