Literature DB >> 24231923

Synthetic cathinones: chemical phylogeny, physiology, and neuropharmacology.

Louis J De Felice1, Richard A Glennon2, Sidney S Negus3.   

Abstract

This mini-review summarizes the history of cathinone and its synthesized derivatives from early records to the present day, including the appearance of synthetic cathinones in the drug combination known as bath salts. Bath salts may consist of one compound (MDPV) or combinations of MDPV and one or more other synthetic cathinones, which may also appear alone without MDPV. We briefly review recent in vitro studies of bath salts components alone or in combination, focusing on pharmacological and biophysical studies. Finally we summarize new data from in vivo procedures that characterize the abuse-related neurochemical and behavioral effects of synthetic cathinones in rats.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Amphetamine; Bath salts; Cocaine; Dopamine; Intracranial selfstimulation (ICSS); MDPV; Mephedrone; Methamphamine; Methcathinone; Methylone; Serotonin; Synthetic cathinones; Transporters

Mesh：

Substances：

Year:  2013        PMID： 24231923      PMCID： PMC3944897          DOI： 10.1016/j.lfs.2013.10.029

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  42 in total

1.  Phenylisopropylamine derivatives, structure and action.

Authors:  J van der SCHOOT; E J ARIENS; J van ROSSUM; J A HURKMANS
Journal:  Arzneimittelforschung       Date:  1962-09

2.  Use of intracranial self-stimulation to evaluate abuse-related and abuse-limiting effects of monoamine releasers in rats.

Authors:  C T Bauer; M L Banks; B E Blough; S S Negus
Journal:  Br J Pharmacol       Date:  2013-02       Impact factor: 8.739

3.  Pharmacological characterization of designer cathinones in vitro.

Authors:  L D Simmler; T A Buser; M Donzelli; Y Schramm; L-H Dieu; J Huwyler; S Chaboz; M C Hoener; M E Liechti
Journal:  Br J Pharmacol       Date:  2013-01       Impact factor: 8.739

4.  Methcathione ("cat"): an enantiomeric potency comparison.

Authors:  R A Glennon; R Young; B R Martin; T A Dal Cason
Journal:  Pharmacol Biochem Behav       Date:  1995-04       Impact factor: 3.533

5.  Dopamine transporter/syntaxin 1A interactions regulate transporter channel activity and dopaminergic synaptic transmission.

Authors:  Lucia Carvelli; Randy D Blakely; Louis J DeFelice
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-03       Impact factor: 11.205

6.  Structure-activity studies on amphetamine analogs using drug discrimination methodology.

Authors:  R A Glennon; R Young; A E Hauck; J D McKenney
Journal:  Pharmacol Biochem Behav       Date:  1984-12       Impact factor: 3.533

7.  Analysis of first and second generation legal highs for synthetic cannabinoids and synthetic stimulants by ultra-performance liquid chromatography and time of flight mass spectrometry.

Authors:  Kevin G Shanks; Tim Dahn; George Behonick; Andrea Terrell
Journal:  J Anal Toxicol       Date:  2012-05-14       Impact factor: 3.367

8.  Further evidence for an amphetamine-like mechanism of action of the alkaloid cathinone.

Authors:  P Kalix; R A Glennon
Journal:  Biochem Pharmacol       Date:  1986-09-15       Impact factor: 5.858

9.  Abuse-related and abuse-limiting effects of methcathinone and the synthetic "bath salts" cathinone analogs methylenedioxypyrovalerone (MDPV), methylone and mephedrone on intracranial self-stimulation in rats.

Authors:  J S Bonano; R A Glennon; L J De Felice; M L Banks; S S Negus
Journal:  Psychopharmacology (Berl)       Date:  2013-08-15       Impact factor: 4.530

10.  Duloxetine inhibits effects of MDMA ("ecstasy") in vitro and in humans in a randomized placebo-controlled laboratory study.

Authors:  Cédric M Hysek; Linda D Simmler; Valentina G Nicola; Nerina Vischer; Massimiliano Donzelli; Stephan Krähenbühl; Eric Grouzmann; Jörg Huwyler; Marius C Hoener; Matthias E Liechti
Journal:  PLoS One       Date:  2012-05-04       Impact factor: 3.240
View more
  28 in total

1.  Structure-activity relationships of bath salt components: substituted cathinones and benzofurans at biogenic amine transporters.

Authors:  Amy J Eshleman; Shanthi Nagarajan; Katherine M Wolfrum; John F Reed; Tracy L Swanson; Aaron Nilsen; Aaron Janowsky
Journal:  Psychopharmacology (Berl)       Date:  2018-11-05       Impact factor: 4.530

2.  Amphetamine maintenance differentially modulates effects of cocaine, methylenedioxypyrovalerone (MDPV), and methamphetamine on intracranial self-stimulation and nucleus accumbens dopamine in rats.

Authors:  Amy R Johnson; Matthew L Banks; Dana E Selley; S Stevens Negus
Journal:  Neuropsychopharmacology       Date:  2018-04-19       Impact factor: 7.853

3.  Comparative Behavioral Pharmacology of Three Pyrrolidine-Containing Synthetic Cathinone Derivatives.

Authors:  Michael B Gatch; Sean B Dolan; Michael J Forster
Journal:  J Pharmacol Exp Ther       Date:  2015-05-21       Impact factor: 4.030

Review 4.  Baths salts, spice, and related designer drugs: the science behind the headlines.

Authors:  Michael H Baumann; Ernesto Solis; Lucas R Watterson; Julie A Marusich; William E Fantegrossi; Jenny L Wiley
Journal:  J Neurosci       Date:  2014-11-12       Impact factor: 6.167

5.  Effects of repeated treatment with methcathinone, mephedrone, and fenfluramine on intracranial self-stimulation in rats.

Authors:  J A Suyama; M L Banks; S S Negus
Journal:  Psychopharmacology (Berl)       Date:  2018-09-19       Impact factor: 4.530

Review 6.  Intracranial self-stimulation to evaluate abuse potential of drugs.

Authors:  S Stevens Negus; Laurence L Miller
Journal:  Pharmacol Rev       Date:  2014-07       Impact factor: 25.468

7.  The Psychoactive Designer Drug and Bath Salt Constituent MDPV Causes Widespread Disruption of Brain Functional Connectivity.

Authors:  Luis M Colon-Perez; Kelvin Tran; Khalil Thompson; Michael C Pace; Kenneth Blum; Bruce A Goldberger; Mark S Gold; Adriaan W Bruijnzeel; Barry Setlow; Marcelo Febo
Journal:  Neuropsychopharmacology       Date:  2016-03-21       Impact factor: 7.853

Review 8.  Neurotoxicology of Synthetic Cathinone Analogs.

Authors:  Mariana Angoa-Pérez; John H Anneken; Donald M Kuhn
Journal:  Curr Top Behav Neurosci       Date:  2017

9.  Decoding the Structure of Abuse Potential for New Psychoactive Substances: Structure-Activity Relationships for Abuse-Related Effects of 4-Substituted Methcathinone Analogs.

Authors:  S Stevens Negus; Matthew L Banks
Journal:  Curr Top Behav Neurosci       Date:  2017

10.  "Ecstasy" to addiction: Mechanisms and reinforcing effects of three synthetic cathinone analogs of MDMA.

Authors:  Sean B Dolan; Zhenglan Chen; Renqi Huang; Michael B Gatch
Journal:  Neuropharmacology       Date:  2018-01-31       Impact factor: 5.250
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.