| Literature DB >> 7193518 |
C Jacobs, S M Kalman, M Tretton, M W Weiner.
Abstract
The renal handling of cis-diamminedichloroplatinum(II) (cisplatin) was investigated by measuring the renal clearance of creatinine and free platinum (Pt). Free Pt clearance exceeded the glomerular filtration rate, indicating secretion of cisplatin or a metabolite. These results suggest that accumulation of Pt within renal tubular cells may be related to its nephrotoxicity.Entities:
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Year: 1980 PMID: 7193518
Source DB: PubMed Journal: Cancer Treat Rep ISSN: 0361-5960