[Anti-inflammatory action of acemetacin (author's transl)].

The anti-inflammatory efficacy of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetoxy]acetic acid (acemetacin, TV 1322, Rantudil) a new non-steroidal anti-inflammatory agent, is described. The stronger inhibition of inflammation in kaolin-induced edema of the rat paw could experimentally be proved with the new compound in comparison with a series of marketed anti-inflammatory agents. Acemetacin is highly effective following both oral and parenteral administration. Following provocation of inflammation in the rat paw by a series of other different agents acemetacin was more strongly effective than indometacin following oral administration. Clear advantage of acemetacin as against indometacin were shown after influencing Freund's adjuvant induced arthritis. In local inflammation too, for example in the wool pellet test, the development of granulation tissue and exudate was inhibited to the same extent as following application of corticosteroid. Both skin erythema and dye-stuff spreading by inhibition of hyaluronidase were antagonised. From the results obtained with acemetacin in numerous inflammatory models conclusion can be drawn as to the multiple sites of action in the reaction chain of inflammation.