Literature DB >> 7190977

Biological properties of 16 alpha-hydroxyestrone: implications in estrogen physiology and pathophysiology.

J Fishman, C Martucci.   

Abstract

Metabolism of estradiol in men with cirrhosis and subjects with systemic lupus erythematosus results in an excessive formation of 16 alpha-hydroxyestrone. Examination of the biological activity of this metabolite showed that it is a potent uterotropic agent and that it exhibits minimal affinity for the human sex hormone-binding globulin. These biological characteristics are consistent with a hyperestrongenic response to the substance, which may be reflected in the pathology and etiology of these diseases.

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Year:  1980        PMID： 7190977     DOI： 10.1210/jcem-51-3-611

Source DB:  PubMed          Journal:  J Clin Endocrinol Metab        ISSN： 0021-972X            Impact factor:   5.958


  27 in total

Review 1.  Impact of sex hormone metabolism on the vascular effects of menopausal hormone therapy in cardiovascular disease.

Authors:  Durr-e-Nayab Masood; Emir C Roach; Katie G Beauregard; Raouf A Khalil
Journal:  Curr Drug Metab       Date:  2010-10       Impact factor: 3.731

2.  Coordinated expression of intermediate biomarkers for tumorigenic transformation in RAS-transfected mouse mammary epithelial cells.

Authors:  N T Telang; R Narayanan; H L Bradlow; M P Osborne
Journal:  Breast Cancer Res Treat       Date:  1991-08       Impact factor: 4.872

Review 3.  Sex, Gender, and Sex Hormones in Pulmonary Hypertension and Right Ventricular Failure.

Authors:  James Hester; Corey Ventetuolo; Tim Lahm
Journal:  Compr Physiol       Date:  2019-12-18       Impact factor: 9.090

Review 4.  The influence of sex hormones on the disease systemic lupus erythematosus.

Authors:  R G Lahita
Journal:  Springer Semin Immunopathol       Date:  1986

Review 5.  Estrogen and catechol amine metabolism: possible interaction during pregnancy.

Authors:  E R Barnea; F Naftolin
Journal:  J Endocrinol Invest       Date:  1987-06       Impact factor: 4.256

6.  Abnormal oxidative metabolism of estradiol in women with breast cancer.

Authors:  J Schneider; D Kinne; A Fracchia; V Pierce; K E Anderson; H L Bradlow; J Fishman
Journal:  Proc Natl Acad Sci U S A       Date:  1982-05       Impact factor: 11.205

7.  Covalent binding of the endogenous estrogen 16 alpha-hydroxyestrone to estradiol receptor in human breast cancer cells: characterization and intranuclear localization.

Authors:  G E Swaneck; J Fishman
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

8.  Serum estrogen metabolites and systolic blood pressure among middle-aged and older women and men.

Authors:  Christopher M Masi; Louise C Hawkley; Xia Xu; Timothy D Veenstra; John T Cacioppo
Journal:  Am J Hypertens       Date:  2009-08-27       Impact factor: 2.689

9.  Abnormalities of sex hormones in men with systemic lupus erythematosus.

Authors:  M Carrabba; C Giovine; M Chevallard; M Angelini; B Ambrosi; P Travaglini
Journal:  Clin Rheumatol       Date:  1985-12       Impact factor: 2.980

10.  Nutrition-endocrine interactions: induction of reciprocal changes in the delta 4-5 alpha-reduction of testosterone and the cytochrome P-450-dependent oxidation of estradiol by dietary macronutrients in man.

Authors:  A Kappas; K E Anderson; A H Conney; E J Pantuck; J Fishman; H L Bradlow
Journal:  Proc Natl Acad Sci U S A       Date:  1983-12       Impact factor: 11.205
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