[Relationship between the spectral properties and antifungal properties of amphoterecin B and candicidine].

The antifungal activities of polyen macrolides Amphotericine B and Candicidine are investigated. The deep spectral changes of the absorption and of the circular dichroism show various states of micellar preparations which are: a) in aqueous medium, aggregats of different spectral characteristics, the antifungal activity of which being modulated by the preparation. b) aggregats of antifungal heptaen with membrane-sterol responsable of the antifongal activity. c) aggregats in hydrophobic solutions which spectroscopic properties are sterol-complex like. Our results suggest an explanation of the spectral changes and can point out some favorable characteristics for an optimal activity of these antifungals against yeasts.