Literature DB >> 7173275

The metabolism and toxicity of paracetamol in Sprague-Dawley and Wistar rats.

S J Hart, I C Calder, J D Tange.   

Abstract

Urinary paracetamol metabolites from Sprague-Dawley and Wistar rats were analysed by reversed-phase HPLC. Variations in the metabolic profile were observed as a function of dose, age, sex, species and route of administration. In addition the effect of 3-methylcholanthrene as an inducer of cytochrome P450 mixed function oxidase on paracetamol metabolism was also studied. Increased oxidative metabolism which lead to the formation of 3-thiomethylparacetamol conjugates along with paracetamol mercapturic acid could be correlated with increased susceptibility to hepatic damage. Furthermore it appears that the length of time taken for excretion and the level of free drug excreted may be involved in the aetiology of chronic renal damage.

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Year:  1982        PMID： 7173275     DOI： 10.1007/BF03189567

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  31 in total

1.  The metabolism of bromazepam in the rat--identification of mercapturic acid and its conversion in vitro to methylthio-bromazepam.

Authors:  M Tateishi; S Suzuki; H Shimizu
Journal:  Biochem Pharmacol       Date:  1978-03-01       Impact factor: 5.858

2.  Comparative metabolic studies of phenacetin and structurally-related compounds in the rat.

Authors:  G E Smith; L A Griffiths
Journal:  Xenobiotica       Date:  1976-04       Impact factor: 1.908

3.  Paracetamol metabolism in the rat: relationship to covalent binding and hepatic damage.

Authors:  M Davis; N G Harrison; G Ideo; B Portmann; D Labadarios; R William
Journal:  Xenobiotica       Date:  1976-04       Impact factor: 1.908

4.  Metabolism of drugs by the kidney.

Authors:  M W Anders
Journal:  Kidney Int       Date:  1980-11       Impact factor: 10.612

5.  N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen.

Authors:  I C Calder; S J Hart; K Healey; K N Ham
Journal:  J Med Chem       Date:  1981-08       Impact factor: 7.446

6.  A disarmed world.

Authors:  K M Ham; I S Robinson; I C Calder; J Mohandas; G G Duggin; J S Horvath; D J Tiller
Journal:  Med J Aust       Date:  1981-05-16       Impact factor: 7.738

7.  N-Hydroxyacetaminophen: a microsomal metabolite of N-hydroxyphenacetin but apparently not of acetaminophen.

Authors:  J A Hinson; L R Pohl; J R Gillette
Journal:  Life Sci       Date:  1979-06-04       Impact factor: 5.037

8.  Metabolism of paracetamol by the isolated perfused kidney of the homozygous Gunn rat.

Authors:  K R Emslie; I C Calder; S J Hart; J D Tange
Journal:  Xenobiotica       Date:  1982-02       Impact factor: 1.908

9.  Paracetamol and renal damage.

Authors:  O M Edwards; P Edwards; E C Huskisson; R T Taylor
Journal:  Br Med J       Date:  1971-04-10

10.  Formation of a thiomethyl metabolite of phenacetin and acetaminophen in dogs and man.

Authors:  A Klutch; W Levin; R L Chang; F Vane; A H Conney
Journal:  Clin Pharmacol Ther       Date:  1978-09       Impact factor: 6.875
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  1 in total

1.  Therapeutic paracetamol treatment in older persons induces dietary and metabolic modifications related to sulfur amino acids.

Authors:  Estelle Pujos-Guillot; Gisèle Pickering; Bernard Lyan; Gilles Ducheix; Marion Brandolini-Bunlon; Françoise Glomot; Dominique Dardevet; Claude Dubray; Isabelle Papet
Journal:  Age (Dordr)       Date:  2011-02-22
  1 in total

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