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Literature DB >> 717179

Effect of dimaprit on gastric acid secretion in conscious cats.

D C Carter, M Impicciatore, M I Grossman.

Abstract

Gastric acid secretion was studied in conscious cats with gastric fistulas. Dimaprit and Nalpha,5-dimethylhistamine produced higher maximal responses than histamine. In the presence of pyrilamine, the maximal response to histamine was equal to that of dimaprit. Pyrilamine increased submaximal but not maximal responses to pentagastrin. Cimetidine decreased the potency of dimaprit but did not alter the maximal response. Gastric acid secretion continued for 90 min after infusion of dimaprit was stopped. Possible mechanisms for the enhancement of acid secretion by pyrilamine include: (a) blocking of an inhibitory histamine H1-receptor and (b) inhibition of histamine methyltransferase.

Entities: Chemical Disease Species

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Year: 1978 PMID： 717179 DOI： 10.1007/bf02111427

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

9 in total

1. An analysis of the depressor responses to histamine in the cat and dog: involvement of both H1- and H2-receptors.

Authors: J W Black; D A Owen; M E Parsons
Journal: Br J Pharmacol Date: 1975-07 Impact factor: 8.739

2. Dimaprit -(S-[3-(N,N-dimethylamino)prophyl]isothiourea) - a highly specific histamine H2 -receptor agonist. Part 1. Pharmacology.

Authors: M E Parsons; D A Owen; C R Ganellin; G J Durant
Journal: Agents Actions Date: 1977-03

3. N-methyl, 5-methyl histamine evokes a higher maximal rate of gastric acid secretion than histamine.

Authors: M Impicciatore; G Bertaccini; F Mossini; D Hansen; M I Grossman
Journal: Proc Soc Exp Biol Med Date: 1977-11

4. Definition and antagonism of histamine H 2 -receptors.

Authors: J W Black; W A Duncan; C J Durant; C R Ganellin; E M Parsons
Journal: Nature Date: 1972-04-21 Impact factor: 49.962

5. Stimulation of gastric acid secretion by 5-methyl histamine incat.

Authors: M Impicciatore; M I Grossman
Journal: Am J Dig Dis Date: 1973-07

6. Studies on the mode of action of histamine H1- and H2-receptor antagonists on gastric histamine methyltransferase.

Authors: H Barth; I Niemeyer; W Lorenz
Journal: Agents Actions Date: 1973-10

7. Proceedings: Histamine receptors in the cardiovascular system of the cat.

Authors: D A Owen; M E Parsons
Journal: Br J Pharmacol Date: 1974-05 Impact factor: 8.739

8. Biological activities of a new specific stimulant of histamine H2 receptors.

Authors: G Bertaccini; M Impicciatore; T Vitali
Journal: Farmaco Sci Date: 1976-12

9. The effects of histamine and some histamine-like agonists on blood pressure in the cat.

Authors: D A Owen
Journal: Br J Pharmacol Date: 1975-10 Impact factor: 8.739

9 in total

7 in total

1. Comparison of the effects of structurally different H2-antagonists on acid and pepsin activity stimulated by dimaprit in conscious cats.

Authors: M Impicciatore; M Chiavarini; G Morini; E Barocelli; E Molina; P V Plazzi
Journal: Agents Actions Date: 1985-09

2. Stimulation of gastric acid secretion by dimaprit in unanesthetized rats.

Authors: H Petersen; M I Grossman
Journal: Agents Actions Date: 1978-12

3. The involvement of histamine receptor subtypes in gastric acid secretion and mucosal blood flow in the anaesthetized rabbit.

Authors: B P Curwain; N C Turner
Journal: J Physiol Date: 1981-02 Impact factor: 5.182

7. Comparison of the agonist activity of impromidine (SK & F 92676) in anaesthetized rabbits and on the rabbit isolated fundic mucosa.

Authors: B P Curwain; N C Turner
Journal: Br J Pharmacol Date: 1981-08 Impact factor: 8.739