| Literature DB >> 7171452 |
M I Saunders, S Dische, D Fermont, A Bishop, I Lenox-Smith, J G Allen, S L Malcolm.
Abstract
A new hypoxic cell radiosensitizer, Ro 03-8799, has been administered i.v. to 2 normal and 6 patient volunteers. Generally in non-necrotic tumours the concentrations obtained were 3 times greater than in plasma sampled at the same time. These observations added to the reports concerning toxicology in monkeys and rats and radiosensitizing efficiency in the laboratory, suggest that Ro 03-8799 may prove to be much more effective sensitizer than misonidazole in man.Entities:
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Year: 1982 PMID： 7171452 PMCID： PMC2011152 DOI： 10.1038/bjc.1982.262
Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640