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Literature DB >> 7170063

Developmental changes in mouse brain polyamine metabolism.

S I Laitinen, P H Laitinen, O A Hietala, A E Pajunen, R S Piha.

Abstract

Mouse brain ornithine decarboxylase (ODC) activity is high at the time of birth, whereas S-adenosyl-L-methionine decarboxylase (SAM-DC) activity is low. ODC activity, and putrescine, spermidine and spermine concentrations decline rapidly during postnatal development to the low level characteristic of mature brains, while SAM-DC activity behaves in the opposite manner. The fluctuations in mouse brain polyamine metabolism are in accord with those found in the rat. The apparent Km values of ODC and SAM-DC for their substrates decline parallel with the decrease of substrate and product concentrations during ontogeny suggesting substrate and/or product dependent regulation of polyamine synthesis in the developing brain.

Entities: Chemical Gene Species

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Year: 1982 PMID： 7170063 DOI： 10.1007/bf00965090

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

27 in total

1. Regulation of rat heart ornithine decarboxylase: change in affinity for ornithine evoked by neuronal, hormonal, and ontogenetic stimuli.

Authors: C Lau; T A Slotkin
Journal: Mol Pharmacol Date: 1979-09 Impact factor: 4.436

Review 2. Polyamines in rapid growth and cancer.

Authors: J Jänne; H Pösö; A Raina
Journal: Biochim Biophys Acta Date: 1978-04-06

3. The effect of DL-allylglycine on polyamine and GABA metabolism in mouse brain.

Authors: A E Pajunen; O A Hietala; E L Baruch-Virransalo; R S Piha
Journal: J Neurochem Date: 1979-05 Impact factor: 5.372

4. Polyamines: developmental alterations in regional disposition and metabolism in rat brain.

Authors: E G Shaskan; J H Haraszti; S H Snyder
Journal: J Neurochem Date: 1973-05 Impact factor: 5.372

5. Perinatal changes in the free amino acid pool of the brain in mice.

Authors: A Lajtha; J Toth
Journal: Brain Res Date: 1973-05-30 Impact factor: 3.252

6. On the purification of L-ornithine decarboxylase from rat prostate and effects of thiol compounds on the enzyme.

Authors: J Jänne; H G Williams-Ashman
Journal: J Biol Chem Date: 1971-03-25 Impact factor: 5.157

7. Regulation of ornithine decarboxylase activity in the developing heart of euthyroid or hyperthyroid rats.

Authors: C Lau; T A Slotkin
Journal: Mol Pharmacol Date: 1980-09 Impact factor: 4.436

8. Histamine and spermidine content in brain during development.

Authors: L A Pearce; S M Schanberg
Journal: Science Date: 1969-12-05 Impact factor: 47.728

9. Tissue distribution of S-adenosylmethionine and S-adenosylhomocysteine in the rat. Effect of age, sex and methionine administration on the metabolism of S-adenosylmethionine, S-adenosylhomocysteine and polyamines.

Authors: T O Eloranta
Journal: Biochem J Date: 1977-09-15 Impact factor: 3.857

4. Interrelationships between ornithine, glutamate, and GABA. II. Consequences of inhibition of GABA-T and ornithine aminotransferase in brain.

Authors: G Daune; N Seiler
Journal: Neurochem Res Date: 1988-01 Impact factor: 3.996

Developmental changes in mouse brain polyamine metabolism.

1. Regulation of rat heart ornithine decarboxylase: change in affinity for ornithine evoked by neuronal, hormonal, and ontogenetic stimuli.

Review 2. Polyamines in rapid growth and cancer.

3. The effect of DL-allylglycine on polyamine and GABA metabolism in mouse brain.

4. Polyamines: developmental alterations in regional disposition and metabolism in rat brain.

5. Perinatal changes in the free amino acid pool of the brain in mice.

6. On the purification of L-ornithine decarboxylase from rat prostate and effects of thiol compounds on the enzyme.

7. Regulation of ornithine decarboxylase activity in the developing heart of euthyroid or hyperthyroid rats.

8. Histamine and spermidine content in brain during development.

9. Tissue distribution of S-adenosylmethionine and S-adenosylhomocysteine in the rat. Effect of age, sex and methionine administration on the metabolism of S-adenosylmethionine, S-adenosylhomocysteine and polyamines.

10. Changes in cadaverine and putrescine metabolism in the mouse kidney induced to growth by an anabolic steroid.

1. Regulation of cytosolic free calcium concentration by intrasynaptic mitochondria.

2. 5-Fluoromethylornithine, an irreversible and specific inhibitor of L-ornithine:2-oxo-acid aminotransferase.

3. A practicable variant of the ion exchange method for the radiometric estimation of ornithine decarboxylase activity.

4. Interrelationships between ornithine, glutamate, and GABA. II. Consequences of inhibition of GABA-T and ornithine aminotransferase in brain.

5. Purification of mouse brain ornithine decarboxylase reveals its presence as an inactive complex with antizyme.

6. Activation of rat brain ornithine decarboxylase by GTP.

Review 7. Polyamine Metabolism and Gene Methylation in Conjunction with One-Carbon Metabolism.