Literature DB >> 7165358

An improved method for evaluating antiandrogens.

C M Goos, P Wirtz, A J Vermorken.   

Abstract

In recent years, the hamster flank organ test has been frequently used to screen compounds for antiandrogenic activity. When used routinely, the diameter of the pigmented spot is used to evaluate the androgenic or antiandrogenic effect of the drug tested. In this article, it is shown that the pigmented spot and the sebaceous glands may respond to a quite different degree to hormonal stimuli, indicating that visual observation alone is insufficient for screening purposes. Determination of sebaceous gland sizes by histochemical techniques allows a better evaluation of androgenic or anti-androgenic effects.

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Year:  1982        PMID： 7165358     DOI： 10.1007/bf00409263

Source DB:  PubMed          Journal:  Arch Dermatol Res        ISSN： 0340-3696            Impact factor:   3.017


  11 in total

1.  The sebaceous glands of the hamster; morphological effects of androgens on integumentary structures.

Authors:  J B HAMILTON; W MONTAGNA
Journal:  Am J Anat       Date:  1950-03

2.  Antiandrogens and reproductive development.

Authors:  F Neumann; W Elger; H Steinbeck
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1970-08-06       Impact factor: 6.237

Review 3.  Inhibitors of sex hormones: development of experimental models.

Authors:  P Frost; E C Gomez
Journal:  Adv Biol Skin       Date:  1972

4.  Biodynamic studies of hamster flank organ growth: hormonal influences.

Authors:  P Frost; J L Giegel; G D Weinstein; E C Gomez
Journal:  J Invest Dermatol       Date:  1973-09       Impact factor: 8.551

5.  The antiandrogenic action of 4-androsten-3-one-17 beta-carboxylic acid and its methyl ester on hamster flank organ.

Authors:  W Voigt; S L Hsia
Journal:  Endocrinology       Date:  1973-04       Impact factor: 4.736

6.  [Influence of antiandrogens on libido, potency and testicular function].

Authors:  F Ott; H Hoffet
Journal:  Schweiz Med Wochenschr       Date:  1968-11-16

7.  Evaluation of the hamster flank organ test for the screening of anti-androgens.

Authors:  A J Vermorken; C M Goos; P Wirtz
Journal:  Br J Dermatol       Date:  1982-01       Impact factor: 9.302

8.  A method for the evaluation of the local antiandrogenic action of 5 alpha-reductase inhibitors on human skin.

Authors:  A J Vermorken; C M Goos; H M Roelofs
Journal:  Br J Dermatol       Date:  1980-06       Impact factor: 9.302

9.  Effect of 13-cis-retinoic acid on the hamster flank organ.

Authors:  E C Gomez; R J Moskowitz
Journal:  J Invest Dermatol       Date:  1980-06       Impact factor: 8.551

10.  The antiandrogenic effect of progesterone on the hamster flank organ.

Authors:  A J Vermorken; C M Goos; H M Roelofs
Journal:  Br J Dermatol       Date:  1980-04       Impact factor: 9.302
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  3 in total

1.  Studies on the local activity of antiandrogens at the molecular and histological level.

Authors:  A J Vermorken; C M Goos; C Sultan; A M Vermeesch-Markslag; A C Dijkstra
Journal:  Mol Biol Rep       Date:  1986       Impact factor: 2.316

2.  The lack of effect of 11 alpha-hydroxyprogesterone on the flank-organ and ear sebaceous glands of adult male Syrian golden hamsters.

Authors:  J R Matias; N Orentreich; V Malloy; C P De Feo; L Matias
Journal:  Arch Dermatol Res       Date:  1984       Impact factor: 3.017

3.  The local antiandrogenic effect of the intracutaneous injection of progesterone in the flank organ of sexually mature male Syrian golden hamster.

Authors:  N Orentreich; J R Matias; V Malloy
Journal:  Arch Dermatol Res       Date:  1984       Impact factor: 3.017
  3 in total

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