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Literature DB >> 7164946

Release of PAF-acether from human blood monocytes.

B Arnoux, E Jouvin-Marche, A Arnoux, J Benveniste.

Abstract

Stimulation of human blood monocytes with ionophore A 23187 induced the release of platelet-activating factor (PAF-acether). Phagocytosis of zymosan, coated or not with complement, bacteria or immune complexes, stimulated the release of PAF-acether whereas that of latex particles was without effect. Such release did not occur at 4 degrees C or in the presence of EDTA. PAF-acether derived from monocytes shared the same characteristics as hog leucocyte PAF-acether or synthetic 1-O-alkyl-2-acetyl-glyceryl-3-phosphorylcholine. In lung physiology, the release of PAF-acether from monocytes and alveolar macrophages could lead, via the platelets, to bronchoconstriction. It could represent a cause for asthma other than the classical IgE-mastocyte interaction.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1982 PMID： 7164946 DOI： 10.1007/bf01965089

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

15 in total

1. Structural analysis of purified platelet-activating factor by lipases.

Authors: J Benveniste; J P Le Couedic; J Polonsky; M Tence
Journal: Nature Date: 1977-09-08 Impact factor: 49.962

2. The release of a platelet-activating factor by stimulated rabbit neutrophils.

Authors: J M Lynch; G Z Lotner; S J Betz; P M Henson
Journal: J Immunol Date: 1979-09 Impact factor: 5.422

3. Destruction of rabbit platelets in the allergic response of sensitized leukocytes. I. Demonstration of a fluid phase intermediate.

Authors: R P Siraganian; A G Osler
Journal: J Immunol Date: 1971-05 Impact factor: 5.422

4. Platelet-activating factor, a new mediator of anaphylaxis and immune complex deposition from rabbit and human basophils.

Authors: J Benveniste
Journal: Nature Date: 1974-06-07 Impact factor: 49.962

5. Release of platelet-activating factor (PAF-acether) from alveolar macrophages by the calcium ionophore A23187 and phagocytosis.

Authors: B Arnoux; D Duval; J Benveniste
Journal: Eur J Clin Invest Date: 1980-12 Impact factor: 4.686

6. Opsonin-independent phagocytosis of activators of the alternative complement pathway by human monocytes.

Authors: J K Czop; D T Fearon; K F Austen
Journal: J Immunol Date: 1978-04 Impact factor: 5.422

7. Platelet-activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives.

Authors: B B Vargaftig; J Lefort; M Chignard; J Benveniste
Journal: Eur J Pharmacol Date: 1980-07-25 Impact factor: 4.432

8. Platelet activating factor (PAF-acether): total synthesis of 1-O-octadecyl 2-O-acetyl sn-glycero-3-phosphoryl choline.

Authors: J J Godfroid; F Heymans; E Michel; C Redeuilh; E Steiner; J Benveniste
Journal: FEBS Lett Date: 1980-07-28 Impact factor: 4.124

9. Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators).

Authors: C A Demopoulos; R N Pinckard; D J Hanahan
Journal: J Biol Chem Date: 1979-10-10 Impact factor: 5.157

10. Release, purification, and characterization of platelet-activating factor (PAF).

Authors: V Tencé; J Polonsky; J P Le Couedic; M J Benveniste
Journal: Biochimie Date: 1980 Impact factor: 4.079

4 in total

1. Identification and characterization of a monocyte-derived neutrophil-activating factor in corticosteroid-resistant bronchial asthma.

Authors: J R Wilkinson; A E Crea; T J Clark; T H Lee
Journal: J Clin Invest Date: 1989-12 Impact factor: 14.808