Literature DB >> 7160469

Regulation of hepatic carnitine palmitoyltransferase activity during the foetal-neonatal transition.

E D Saggerson, C A Carpenter.   

Abstract

Overt carnitine palmitoyl transferase (CPT1) activity was measured in liver mitochondria from foetal rats (21 days gestation) and from neonatal rats (1 day post-partum). Birth was accompanied by a 6-fold increase in CPT1 activity, a 14-fold decrease in sensitivity to inhibition by malonyl CoA and an increase in the nH and the S0.5 for palmitoyl CoA. The activity of latent enzyme (CPT2) was unaffected at birth.

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Year:  1982        PMID： 7160469     DOI： 10.1016/0014-5793(82)81329-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

1.  Induction of ketogenesis and fatty acid oxidation by glucagon and cyclic AMP in cultured hepatocytes from rabbit fetuses. Evidence for a decreased sensitivity of carnitine palmitoyltransferase I to malonyl-CoA inhibition after glucagon or cyclic AMP treatment.

Authors:  J P Pégorier; M V Garcia-Garcia; C Prip-Buus; P H Duée; C Kohl; J Girard
Journal:  Biochem J       Date:  1989-11-15       Impact factor: 3.857

2.  Evidence that the sensitivity of carnitine palmitoyltransferase I to inhibition by malonyl-CoA is an important site of regulation of hepatic fatty acid oxidation in the fetal and newborn rabbit. Perinatal development and effects of pancreatic hormones in cultured rabbit hepatocytes.

Authors:  C Prip-Buus; J P Pegorier; P H Duee; C Kohl; J Girard
Journal:  Biochem J       Date:  1990-07-15       Impact factor: 3.857

3.  Binding of malonyl-CoA to isolated mitochondria. Evidence for high- and low-affinity sites in liver and heart and relationship to inhibition of carnitine palmitoyltransferase activity.

Authors:  M I Bird; E D Saggerson
Journal:  Biochem J       Date:  1984-09-15       Impact factor: 3.857

4.  The effect of dexamethasone treatment on the expression of the regulatory genes of ketogenesis in intestine and liver of suckling rats.

Authors:  G Arias; G Asins; F G Hegardt; D Serra
Journal:  Mol Cell Biochem       Date:  1998-01       Impact factor: 3.396

Review 5.  Regulation of cardiac energy metabolism in newborn.

Authors:  Arzu Onay-Besikci
Journal:  Mol Cell Biochem       Date:  2006-05-03       Impact factor: 3.396

6.  Carnitine palmitoyltransferase in liver and five extrahepatic tissues in the rat. Inhibition by DL-2-bromopalmitoyl-CoA and effect of hypothyroidism.

Authors:  E D Saggerson; C A Carpenter
Journal:  Biochem J       Date:  1986-05-15       Impact factor: 3.857

7.  Development and characterization of a polyclonal antibody against rat liver mitochondrial overt carnitine palmitoyltransferase (CPT I). Distinction of CPT I from CPT II and of isoforms of CPT I in different tissues.

Authors:  M P Kolodziej; P J Crilly; C G Corstorphine; V A Zammit
Journal:  Biochem J       Date:  1992-03-01       Impact factor: 3.857

8.  Development and regulation of ketogenesis in hepatocytes isolated from newborn rats.

Authors:  P Ferré; P Satabin; J F Decaux; F Escriva; J Girard
Journal:  Biochem J       Date:  1983-09-15       Impact factor: 3.857

9.  Effects of labor on placental fatty acid β oxidation.

Authors:  Hector Mendez-Figueroa; Edward K Chien; Huiling Ji; Nicole L Nesbitt; Sivakama S Bharathi; Eric Goetzman
Journal:  J Matern Fetal Neonatal Med       Date:  2012-11-02

10.  Developmental changes in carnitine palmitoyltransferases I and II gene expression in intestine and liver of suckling rats.

Authors:  G Asins; D Serra; G Arias; F G Hegardt
Journal:  Biochem J       Date:  1995-03-01       Impact factor: 3.857
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