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Literature DB >> 7159275

Inhibitory effect of betahistine on polysynaptic neurons in the lateral vestibular nucleus.

H Unemoto, M Sasa, S Takaori, J Ito, I Matsuoka.

Abstract

Effects of betahistine, an antivertigo drug, were examined on the lateral vestibular nucleus (LVN) neurons of cats anesthetized with alpha-chloralose. Spike generation of monosynaptic LVN neurons elicited by vestibular nerve stimulation remained unaffected with intravenous administration of betahistine up to 5 mg/kg and with iontophoretic application of the drug up to 200 nA. In contrast, the spike generation of polysynaptic I neurons in the LVN was dose-dependently inhibited by intravenous as well as iontophoretic application of betahistine. These results suggest that small doses of betahistine more selectively interfere with synaptic transmission in the polysynaptic I neurons than in the monosynaptic neurons.

Entities: Chemical Species

Mesh：

Substances：
Pyridines
Betahistine

Year: 1982 PMID： 7159275 DOI： 10.1007/bf00454214

Source DB: PubMed Journal: Arch Otorhinolaryngol ISSN： 0302-9530

15 in total

1. Effects of diphenhydramine and dimenhydrinate on vestibular neuronal activity of cat: a search for the locus of their antimotion sickness action.

Authors: B P Jaju; S C Wang
Journal: J Pharmacol Exp Ther Date: 1971-03 Impact factor: 4.030

2. Ménière's disease.

Authors: J J Hicks; J N Hicks; H N Cooley
Journal: Arch Otolaryngol Date: 1967-12

3. Functional connections of tonic and kinetic vestibular neurons with primary vestibular afferents.

Authors: W Precht; H Shimazu
Journal: J Neurophysiol Date: 1965-11 Impact factor: 2.714

4. Pathogenesis and management of Ménière's syndrome in terms of microcirculation. Pharmacologic decompression of the endolymphatic hydrops.

Authors: Z Godlowski
Journal: Angiology Date: 1965-11 Impact factor: 3.619

Review 6. Betahistine for tinnitus.

Authors: Inge Wegner; Deborah A Hall; Adriana Leni Smit; Don McFerran; Inge Stegeman
Journal: Cochrane Database Syst Rev Date: 2018-12-28

6 in total

Inhibitory effect of betahistine on polysynaptic neurons in the lateral vestibular nucleus.

1. Effects of diphenhydramine and dimenhydrinate on vestibular neuronal activity of cat: a search for the locus of their antimotion sickness action.

2. Ménière's disease.

3. Functional connections of tonic and kinetic vestibular neurons with primary vestibular afferents.

4. Pathogenesis and management of Ménière's syndrome in terms of microcirculation. Pharmacologic decompression of the endolymphatic hydrops.

5. Orally administered betahistine and regional cerebral blood flow in cerebrovascular disease.

6. Microiontophoretic studies on noradrenergic inhibition from locus coeruleus of spinal trigeminal nucleus neurons.

7. Effects of betahistine HCl, nicotinic acid, and histamine on basilar blood flow in anesthetized dogs.

8. Comparative responses of the carotid and vertebral arterial systems of rhesus monkeys to betahistine.

9. Selective effect of cinnarizine on the vestibular nucleus neurons.

10. Selective effect of ethanol on the vestibular nucleus neurons in the cat.

1. Meta-analysis of clinical studies with betahistine in Ménière's disease and vestibular vertigo.

Review 2. Histamine and betahistine in the treatment of vertigo: elucidation of mechanisms of action.

3. Betahistine in the treatment of vertiginous syndromes: a meta-analysis.

Review 4. Antivertigo medications and drug-induced vertigo. A pharmacological review.

5. Management of acute vertigo with betahistine.

Review 6. Betahistine for tinnitus.