| Literature DB >> 7159207 |
A E Balant-Gorgia, P Schulz, P Dayer, L Balant, A Kubli, C Gertsch, G Garrone.
Abstract
We have measured the metabolites (demethylated and hydroxylated) of amitriptyline in a group of seven normal volunteers. They were phenotyped as extensive or poor metabolizers using debrisoquine and bufuralol. The results demonstrate that the oxidative metabolism (aliphatic hydroxylation) of amitriptyline is under the same genetic control as that of debrisoquine and bufuralol. However, phenotypic polymorphism cannot be used to predict amitriptyline blood concentration after a single oral dose, since the principal metabolic pathway of amitriptyline is demethylation and not aliphatic hydroxylation.Entities:
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Year: 1982 PMID： 7159207 DOI： 10.1007/bf02141782
Source DB: PubMed Journal: Arch Psychiatr Nervenkr (1970)