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Literature DB >> 7153875

Estimating the fraction reabsorbed in drugs undergoing enterohepatic circulation.

Abstract

A simple method of estimating the extent of biliary recycling using blood level and cumulative biliary excretion data from control and bile duct-cannulated animals is described. The method was tested in rats following an intravenous dose of [14C] temazepam. It was shown that 62% of the drug excreted in the bile of control rats was reabsorbed during each enterohepatic cycle, contributing to the secondary peak blood concentrations and a prolonged elimination half-life.

Entities: Chemical Species

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Year: 1982 PMID： 7153875 DOI： 10.1007/bf01065175

Source DB: PubMed Journal: J Pharmacokinet Biopharm ISSN： 0090-466X

9 in total

Review 1. Influence of gut microflora on bioavailability.

Authors: H G Boxenbaum; I Bekersky; M L Jack; S A Kaplan
Journal: Drug Metab Rev Date: 1979 Impact factor: 4.518

2. Pharmacokinetics of drugs subject to enterohepatic circulation.

Authors: H S Chen; J F Gross
Journal: J Pharm Sci Date: 1979-06 Impact factor: 3.534

3. Pharmacokinetics and metabolism of temazepam in man and several animal species.

Authors: H J Schwarz
Journal: Br J Clin Pharmacol Date: 1979 Impact factor: 4.335

4. Pharmacokinetic and biopharmaceutic parameters during enterohepatic circulation of drugs.

Authors: W A Colburn
Journal: J Pharm Sci Date: 1982-01 Impact factor: 3.534

5. A theoretical examination of the effects of gut wall metabolism, hepatic elimination, and enterohepatic recycling on estimates of bioavailability and of hepatic blood flow.

Authors: K S Pang; J R Gillette
Journal: J Pharmacokinet Biopharm Date: 1978-10

6. A pharmacokinetic model for enterohepatic recirculation in the rat: phenolphthalein, a model drug.

Authors: W A Colburn; P C Hirom; R J Parker; P Milburn
Journal: Drug Metab Dispos Date: 1979 Mar-Apr Impact factor: 3.922

7. A practical method for monitoring drug excretion and enterohepatic circulation in the rat.

Authors: F L Tse; F Ballard; J M Jaffe
Journal: J Pharmacol Methods Date: 1982-03

8. Pharmacokinetic interpretation of the enterohepatic recirculation and first-pass elimination of morphine in the rat.

Authors: B E Dahlström; L K Paalzow
Journal: J Pharmacokinet Biopharm Date: 1978-12

9. Enterohepatic circulation of radioactivity following an oral dose of [14C]temazepam in the rat.

Authors: F L Tse; F Ballard; J M Jaffe; H J Schwarz
Journal: J Pharm Pharmacol Date: 1983-04 Impact factor: 3.765

9 in total

12 in total

1. General treatment of the enterohepatic recirculation of drugs and its influence on the area under the plasma level curves, bioavailability, and clearance.

Authors: J E Peris-Ribera; F Torres-Molina; M C Garcia-Carbonell; J C Aristorena; L Granero
Journal: Pharm Res Date: 1992-10 Impact factor: 4.200

Review 2. Multiple peaking phenomena in pharmacokinetic disposition.

Authors: Neal M Davies; Jody K Takemoto; Dion R Brocks; Jaime A Yáñez
Journal: Clin Pharmacokinet Date: 2010-06 Impact factor: 6.447

3. Necessary modification of formulae estimating the reabsorption rate for drugs subject to enterohepatic recirculation.

Authors: M Kurita
Journal: J Pharmacokinet Biopharm Date: 1991-08

4. A Generic Model for Quantitative Prediction of Interactions Mediated by Efflux Transporters and Cytochromes: Application to P-Glycoprotein and Cytochrome 3A4.

Authors: Michel Tod; S Goutelle; N Bleyzac; L Bourguignon
Journal: Clin Pharmacokinet Date: 2019-04 Impact factor: 6.447

5. Physiologic and metabolic influences on enterohepatic recirculation: simulations based upon the disposition of valproic acid in the rat.

Authors: G M Pollack; K L Brouwer
Journal: J Pharmacokinet Biopharm Date: 1991-04