| Literature DB >> 7098496 |
F L Tse, F Ballard, J M Jaffe.
Abstract
An improved experimental design for studying the enterohepatic circulation of drugs in a pair of bile duct-duodenum cannula-linked rats is described. By housing the rats in individual metabolism cages and using a peristaltic pump to immediately deliver bile secreted by the donor directly into the duodenum of the recipient, the method permits a realistic approximation of biliary excretion and reabsorption in intact animals for periods up to 96 hours.Entities:
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Year: 1982 PMID： 7098496 DOI： 10.1016/0160-5402(82)90026-2
Source DB: PubMed Journal: J Pharmacol Methods ISSN： 0160-5402