Literature DB >> 7151855

Large granular lymphocytes: morphological studies.

D Huhn, C Huber, G Gastl.   

Abstract

Large granular lymphocytes from normal human blood were enriched by centrifugation on discontinuous Percoll density gradients. Their capacity for natural killing, but not for phagocytosis of yeast cells, was demonstrated. Large granular lymphocytes are characterized in electron microscopy by their fine structure, especially by typical granules and by inclusions of tubular structures in a parallel array. Their lymphocyte nature is supported by activity of acid-alpha-naphthyl acetate esterase and by the absence of myelo-peroxidase (POX) and of macrophage POX. The Fc gamma receptor of their cell membrane is marked by soluble POX-anti-POX-complexes; labeled parts of their membrane are not incorporated into the cytoplasm as in monocytes.

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Year:  1982        PMID： 7151855     DOI： 10.1002/eji.1830121118

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  11 in total

1.  Immunoelectron microscopic observations on Leu-7 positive cells in virus-related chronic liver diseases.

Authors:  H Himeno; H Enzan; T Saibara; S Onishi; Y Yamamoto
Journal:  Virchows Arch       Date:  1994       Impact factor: 4.064

2.  Lymphocytosis of large granular lymphocytes associated with anemia and neutropenia: proof of monoclonality of the LGL-population, but benign clinical course.

Authors:  S Serke; A Neubauer; D Huhn
Journal:  Klin Wochenschr       Date:  1989-06-01

Review 3.  Abnormal expansions of granular lymphocytes: reactive lymphocytosis or chronic leukemia? Case report and literature review.

Authors:  G Gastl; H Rumpold; D Kraft; C Gattringer; G Schuler; R Margreiter; F Schmalzl; C Huber
Journal:  Blut       Date:  1986-02

4.  Leu-7-positive cells with monocyte phenotype show different ultrastructural features in comparison to Leu-7-positive cells with T-cell phenotype.

Authors:  G C Manara; G De Panfilis; C Ferrari; A Bonati; G Rocchi; R Scandroglio
Journal:  Histochemistry       Date:  1985

5.  Interferon-alpha induction of lymphocytes containing parallel tubular structures.

Authors:  Y L Hoogeveen; J W Smit; N R Blom; M J van Luyn; R M Halie
Journal:  Blut       Date:  1988-02

6.  Localization and characterization of T-cell subpopulations and natural killer cells (HNK 1+ cells) in the human tonsilla palatina. An ultrastructural-immunocytochemical study.

Authors:  B von Gaudecker; U Pfingsten; H K Müller-Hermelink
Journal:  Cell Tissue Res       Date:  1984       Impact factor: 5.249

7.  Effect of sera from patients with Hodgkin's disease on normal donor lymphocytes containing parallel tubular structures.

Authors:  J W Smit; N R Blom; M J van Luyn; G W van Imhoff; M R Halie
Journal:  Blut       Date:  1984-02

8.  T cells in patients with chronic T gamma lymphocytosis: morphology, cytochemistry, ultrastructure and immunological characteristics.

Authors:  J W Smit; N R Blom; M J van Luyn; F Miedema; C J Melief; M R Halie
Journal:  Blut       Date:  1985-08

9.  Lytic susceptibility of target cells to cytotoxic T cells is determined by their constitutive major histocompatibility complex class I antigen expression and cytokine-induced activation status.

Authors:  M Ritter; C Huber; J Auböck; H Pohl-Markl; J Troppmair; M Herold; A Gächter; W Nussbaumer; G Böck; D Nachbaur
Journal:  Immunology       Date:  1994-04       Impact factor: 7.397

10.  Natural killer cells activated in a human mixed lymphocyte response culture identified by expression of Leu-11 and class II histocompatibility antigens.

Authors:  J H Phillips; A M Le; L L Lanier
Journal:  J Exp Med       Date:  1984-04-01       Impact factor: 14.307
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