Literature DB >> 2545968

Lymphocytosis of large granular lymphocytes associated with anemia and neutropenia: proof of monoclonality of the LGL-population, but benign clinical course.

S Serke1, A Neubauer, D Huhn.   

Abstract

A 37-year-old man with severe transfusion-requiring anemia and neutropenia associated with lymphocytosis of large granular lymphocytes (LGLs) has been followed over a period of 3.5 years. Detailed phenotyping of the LGL has been performed, revealing a phenotype of CD3+, CD8+, CD16+, HLA-DR+, and Leu-7+. Southern-blot analysis of the T-cell receptor beta-chain locus detected a gene rearrangement, thus providing proof of monoclonality of the peripheral blood LGLs.

Entities:  

Mesh：

Year:  1989        PMID： 2545968     DOI： 10.1007/BF01721686

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  29 in total

1.  Lymphocyte activation by phytohaemagglutinin and pokeweed mitogen. Identification of proliferating cells by monoclonal antibodies.

Authors:  S Serke; M Serke; O Brudler
Journal:  J Immunol Methods       Date:  1987-05-20       Impact factor: 2.303

2.  Large granular lymphocytes have a promoting activity on human peripheral blood erythroid burst-forming units.

Authors:  V Pistoia; R Ghio; A Nocera; A Leprini; A Perata; M Ferrarini
Journal:  Blood       Date:  1985-02       Impact factor: 22.113

3.  RAEB in a patient with chronic granulated T-lymphocytosis.

Authors:  R Bassan; B Marini; P Allavena; A Pirelli; T Barbui
Journal:  Br J Haematol       Date:  1987-04       Impact factor: 6.998

4.  Chronic T-cell lymphocytosis with neutropenia: report of a case studied with monoclonal antibody.

Authors:  A C Aisenberg; B M Wilkes; N L Harris; K A Ault; R W Carey
Journal:  Blood       Date:  1981-10       Impact factor: 22.113

5.  Large granular lymphocyte leukemia. Report of 38 cases and review of the literature.

Authors:  T P Loughran; G Starkebaum
Journal:  Medicine (Baltimore)       Date:  1987-09       Impact factor: 1.889

6.  Neutropenia associated with large granular lymphocytes responsive to corticosteroids in vitro and in vivo.

Authors:  L Platanias; E Raefsky; N Young
Journal:  Eur J Haematol       Date:  1987-01       Impact factor: 2.997

7.  Large granular lymphocytes from patients with expanded LGL populations acquire cytotoxic functions and release lymphokines upon in vitro activation.

Authors:  V Pistoia; E F Prasthofer; A B Tilden; J C Barton; M Ferrarini; C E Grossi; K Zuckerman
Journal:  Blood       Date:  1986-11       Impact factor: 22.113

8.  T cell receptor gene rearrangements define a monoclonal T cell proliferation in patients with T cell lymphocytosis and cytopenia.

Authors:  N Berliner; A D Duby; D C Linch; C Murre; T Quertermous; L J Knott; T Azin; A C Newland; D L Lewis; M C Galvin
Journal:  Blood       Date:  1986-04       Impact factor: 22.113

9.  Aggressive natural killer cell leukemia in an adult with establishment of an NK cell line.

Authors:  L A Fernandez; B Pope; C Lee; E Zayed
Journal:  Blood       Date:  1986-04       Impact factor: 22.113

10.  Spontaneous regression of a monoclonal proliferation of large granular lymphocytes associated with reversal of anemia and neutropenia.

Authors:  E F Winton; W C Chan; I Check; K W Colenda; K F Bongiovanni; T A Waldmann
Journal:  Blood       Date:  1986-05       Impact factor: 22.113
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