Literature DB >> 714876

Preparation and spectral properties of 12-hydroxyl eicosatetraenoic acid (HETE).

J C McGuire, R C Kelly, R R Gorman, F F Sun.   

Abstract

A convenient method for the biosynthesis of 12L-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE) from archidonic acid with human platelets was developed, and milligram quantities were made for biological and spectroscopic characterization. This compound has only weak activity in two of five biological prostaglandin assays and no activity in the other three. The 13C and 1H NMR spectra of HETE were obtained and the signal due to each carbon atom was assigned.

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Year:  1978        PMID： 714876     DOI： 10.1080/00327487808069056

Source DB:  PubMed          Journal:  Prep Biochem        ISSN： 0032-7484


  6 in total

1.  Modulation of human neutrophil function by monohydroxy-eicosatetraenoic acids.

Authors:  E J Goetzl; A R Brash; A I Tauber; J A Oates; W C Hubbard
Journal:  Immunology       Date:  1980-04       Impact factor: 7.397

2.  Consequences of cell membrane attack by complement: release of arachidonate and formation of inflammatory derivatives.

Authors:  D K Imagawa; N E Osifchin; W A Paznekas; M L Shin; M M Mayer
Journal:  Proc Natl Acad Sci U S A       Date:  1983-11       Impact factor: 11.205

3.  Specific inhibition of the polymorphonuclear leukocyte chemotactic response to hydroxy-fatty acid metabolites of arachidonic acid by methyl ester derivatives.

Authors:  E J Goetzl; F H Valone; V N Reinhold; R R Gorman
Journal:  J Clin Invest       Date:  1979-06       Impact factor: 14.808

4.  A role for endogenous mono-hydroxy-eicosatetraenoic acids (HETEs) in the regulation of human neutrophil migration.

Authors:  E J Goetzl
Journal:  Immunology       Date:  1980-08       Impact factor: 7.397

5.  Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils.

Authors:  E J Goetzl; F F Sun
Journal:  J Exp Med       Date:  1979-08-01       Impact factor: 14.307

6.  Stimulus specificity of the generation of leukotrienes by dog mastocytoma cells.

Authors:  E J Goetzl; M J Phillips; W M Gold
Journal:  J Exp Med       Date:  1983-09-01       Impact factor: 14.307
  6 in total

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