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Literature DB >> 458381

Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils.

Abstract

Incubation of [3H]arachidonic acid with the 17,000-g supernatant from homogenates of human neutrophils in the presence of indomethacin generated the unique metabolites 9-OH-5,7,11,14-eicosatetraenoic acid (9-HETE) and 8-HETE, in addition to 12-HETE, 11-HETE and 5-HETE. The human neutrophil chemotactic activity of the HETE products exhibited a rank-order of potency with 5-HETE greater than 8-HETE = 9-HETE greater than 11-HETE = 12-HETE. The expression of chemokinetic activity as well as chemotactic activity suggested that the endogenous production of these principles may influence the mobility of human neutrophils.

Entities: Chemical Species

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Year: 1979 PMID： 458381 PMCID： PMC2185634 DOI： 10.1084/jem.150.2.406

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

7 in total

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Authors: P P Ho; C P Walters; H R Sullivan
Journal: Biochem Biophys Res Commun Date: 1976-05-23 Impact factor: 3.575

2. Arachidonate lipoxygenase in blood platelets.

Authors: D H Nugteren
Journal: Biochim Biophys Acta Date: 1975-02-20

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Authors: E J Goetzl; R R Gorman
Journal: J Immunol Date: 1978-02 Impact factor: 5.422

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Authors: P Borgeat; M Hamberg; B Samuelsson
Journal: J Biol Chem Date: 1976-12-25 Impact factor: 5.157

5. Stimulation of human eosinophil and neutrophil polymorphonuclear leukocyte chemotaxis and random migration by 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid.

Authors: E J Goetzl; J M Woods; R R Gorman
Journal: J Clin Invest Date: 1977-01 Impact factor: 14.808

6. Chemotactic factor receptors of human PMN leucocytes. I. Effects on migration of labelling plasma membrane determinants with impermeant covalent reagents and inhibition of labelling by chemotactic factors.

Authors: E J Goetzl; K Y Hoe
Journal: Immunology Date: 1979-06 Impact factor: 7.397

7. Preparation and spectral properties of 12-hydroxyl eicosatetraenoic acid (HETE).

Authors: J C McGuire; R C Kelly; R R Gorman; F F Sun
Journal: Prep Biochem Date: 1978

7 in total

45 in total

Review 1. Modulation of phagocytic cell function.

Authors: P A Henricks; J Verhoef; F P Nijkamp
Journal: Vet Res Commun Date: 1986-05 Impact factor: 2.459

2. Role for endotoxin in the leukocyte infiltration accompanying Escherichia coli inflammation.

Authors: A C Issekutz; S Bhimji
Journal: Infect Immun Date: 1982-05 Impact factor: 3.441

3. Sulfasalazine inhibits the synthesis of chemotactic lipids by neutrophils.

Authors: W F Stenson; E Lobos
Journal: J Clin Invest Date: 1982-02 Impact factor: 14.808

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Authors: J T O'Flaherty; M J Thomas; C J Lees; C E McCall
Journal: Am J Pathol Date: 1981-07 Impact factor: 4.307

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Authors: K A Potter; R W Leid; P E Kolattukudy; K E Espelie
Journal: Am J Pathol Date: 1985-11 Impact factor: 4.307

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Authors: H B Benestad; I B Hersleth
Journal: Blut Date: 1984-04

7. Therapeutic reduction of ongoing carrageenin-induced inflammation by lipoxygenase, but not cyclooxygenase inhibitors.

Authors: M P Holsapple; G K Yim
Journal: Inflammation Date: 1984-09 Impact factor: 4.092

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Authors: F P Nijkamp; J M Sitsen
Journal: Pharm Weekbl Sci Date: 1982-12-17

9. Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis.

Authors: L B Klickstein; C Shapleigh; E J Goetzl
Journal: J Clin Invest Date: 1980-11 Impact factor: 14.808

10. Transformation of arachidonic acid into monohydroxy-eicosatetraenoic acids by mouse peritoneal macrophages.

Authors: H Rabinovitch; J Durand; M Rigaud; F Mendy; J C Breton
Journal: Lipids Date: 1981-07 Impact factor: 1.880