Literature DB >> 7124905

Morphometric studies of the renomedullary interstitial cells of Dahl hypertension-prone and hypertension-resistant rats.

J A Pitcock, P S Brown, J P Rapp, J Crofton, E E Muirhead.   

Abstract

Two strains of rats, one genetically sensitive (the Dahl S rat) and the other resistant (the Dahl R rat) to the hypertensive effect of a high-salt diet were studied morphometrically for determination of whether any anatomic differences were present in the renomedullary interstitial cells (RICs) that might help explain these strain differences. The rats resistant to the hypertensive effects of sodium chloride had more RIC than those from the sensitive strain. In addition, they were more heavily granulated. These findings may be related to the known antihypertensive function of the RICs and may help explain observed differences in the prostaglandin metabolism of the Dahl S and R rats.

Entities:  

Mesh:

Year:  1982        PMID: 7124905      PMCID: PMC1916052     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN: 0002-9440            Impact factor:   4.307


  14 in total

1.  Role of genetic factors in susceptibility to experimental hypertension due to chronic excess salt ingestion.

Authors:  L K DAHL; M HEINE; L TASSINARI
Journal:  Nature       Date:  1962-05-05       Impact factor: 49.962

2.  Genetic influence of the kidneys on blood pressure. Evidence from chronic renal homografts in rats with opposite predispositions to hypertension.

Authors:  L K Dahl; M Heine; K Thompson
Journal:  Circ Res       Date:  1974-01       Impact factor: 17.367

3.  Genetic influence of renal homografts on the blood pressure of rats from different strains.

Authors:  L K Dahl; M Heine; K Thompson
Journal:  Proc Soc Exp Biol Med       Date:  1972-07

4.  Identification of prostaglandin E2 as the principal vasodepressor lipid of rabbit renal medulla.

Authors:  E G Daniels; J W Hinman; B E Leach; E E Muirhead
Journal:  Nature       Date:  1967-09-16       Impact factor: 49.962

5.  Primary role of renal homografts in setting chronic blood pressure levels in rats.

Authors:  L K Dahl; M Heine
Journal:  Circ Res       Date:  1975-06       Impact factor: 17.367

6.  Low renal papillary plasma flow in both Dahl and Kyoto rats with spontaneous hypertension.

Authors:  M Ganguli; L Tobian; L Dahl
Journal:  Circ Res       Date:  1976-09       Impact factor: 17.367

7.  Derivation of antihypertensive neutral renomedullary lipid from renal venous effluent.

Authors:  E E Muirhead; L W Byers; D M Desiderio; J A Pitcock; B Brooks; P S Brown; W L Brosius
Journal:  J Lab Clin Med       Date:  1982-01

8.  Prostaglandin E2 biosynthesis by rabbit renomedullary interstitial cells in tissue culture. Mechanism of stimulation by angiotensin II, bradykinin, and arginine vasopressin.

Authors:  R M Zusman; H R Keiser
Journal:  J Biol Chem       Date:  1977-03-25       Impact factor: 5.157

9.  Renomedullary deficiency in partial nephrectomy-salt hypertension.

Authors:  J A Pitcock; P S Brown; B Brooks; W L Clapp; W L Brosius; E E Muirhead
Journal:  Hypertension       Date:  1980 May-Jun       Impact factor: 10.190

10.  Effects of chronia excess salt ingestion. Evidence that genetic factors play an important role in susceptibility to experimental hypertension.

Authors:  L K DAHL; M HEINE; L TASSINARI
Journal:  J Exp Med       Date:  1962-06-01       Impact factor: 14.307

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