Literature DB >> 845160

Prostaglandin E2 biosynthesis by rabbit renomedullary interstitial cells in tissue culture. Mechanism of stimulation by angiotensin II, bradykinin, and arginine vasopressin.

R M Zusman, H R Keiser.   

Abstract

The mechanism of hormone-stimulated prostaglandin E2 biosynthesis was investigated in rabbit renomedullary interstitial cells in tissue culture. Angiotensin II, bradykinin, and arginine vasopressin stimulated arachidonic acid release and subsequent prostaglandin biosynthesis. Indomethacin completely inhibited prostaglandin biosynthesis without affecting arachidonic acid release. Mepacrine, a phospholipase inhibitor, inhibited arachidonic acid release without affecting subsequent synthesis of prostaglandin E2. Our studies suggest that arachidonic acid release via hormone-activated phospholipase or acylhydrolase (or both) is the mechanism of hormone-stimulated prostaglandin E2 biosynthesis.

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Year:  1977        PMID： 845160

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  24 in total

1.  Rapid inactivation of cyclooxygenase activity after stimulation of intact platelets.

Authors:  E G Lapetina; P Cuatrecasas
Journal:  Proc Natl Acad Sci U S A       Date:  1979-01       Impact factor: 11.205

2.  Diuretic, Natriuretic, and Vasodepressor Activity of a Lipid Fraction Enhanced in Medium of Cultured Mouse Medullary Interstitial Cells by a Selective Fatty Acid Amide Hydrolase Inhibitor.

Authors:  Zdravka Daneva; Sara K Dempsey; Ashfaq Ahmad; Ningjun Li; Pin-Lan Li; Joseph K Ritter
Journal:  J Pharmacol Exp Ther       Date:  2018-12-07       Impact factor: 4.030

3.  Prostaglandin biosynthesis by rabbit renomedullary interstitial cells in tissue culture. Stimulation by angiotensin II, bradykinin, and arginine vasopressin.

Authors:  R M Zusman; H R Keiser
Journal:  J Clin Invest       Date:  1977-07       Impact factor: 14.808

Review 4.  Role of prostaglandin E (PGE) in the modulation of the action of vasopressin on water flow in the urinary bladder of the toad and mammalian kidney.

Authors:  J Orloff; R Zusman
Journal:  J Membr Biol       Date:  1978       Impact factor: 1.843

5.  Arachidonic acid metabolites, hypertension and arteriosclerosis.

Authors:  P C Weber; W Siess; B Scherer; E Held; H Witzgall; R Lorenz
Journal:  Klin Wochenschr       Date:  1982-05-17

6.  Effects of osmolality and antidiuretic hormone on prostaglandin synthesis by renal papilla. Study in Brattleboro rats with diabetes insipidus.

Authors:  N Bouby; M M Trinh-Trang-Tan; M Douté; L Bankir
Journal:  Pflugers Arch       Date:  1984-01       Impact factor: 3.657

7.  The role of calcium in the stimulation of prostaglandin synthesis by vasopressin in rabbit renal-medullary interstitial cells in tissue culture.

Authors:  D A Ausiello; R M Zusman
Journal:  Biochem J       Date:  1984-05-15       Impact factor: 3.857

8.  Formation and action of prostaglandins in the kidney.

Authors:  P C Weber; B Scherer; W Siess; E Held; J Schnermann
Journal:  Klin Wochenschr       Date:  1979-10-01

9.  Vasopressin-stimulated prostaglandin E biosynthesis in the toad urinary bladder. Effect of water flow.

Authors:  R M Zusman; H R Keiser; J S Handler
Journal:  J Clin Invest       Date:  1977-12       Impact factor: 14.808

10.  Inhibition of vasopressin-stimulated prostaglandin E biosynthesis by chlorpropamide in the toad urinary bladder. Mechanism of enhancement of vasopressin-stimulated water flow.

Authors:  R M Zusman; H R Keiser; J S Handler
Journal:  J Clin Invest       Date:  1977-12       Impact factor: 14.808
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