Literature DB >> 7115281

A new genetic variation of the malate dehydrogenase-like enzyme (MDL-1) in inbred rats and its possible linkage.

K Matsumoto, A Matsuhashi, M Aizawa.   

Abstract

A new polymorphism in the mitochondrial fraction of kidney homogenates was found by using discontinuous polyacrylamide gel electrophoresis. The polymorphism is tentatively designated MDL-1, since the enzyme was visualized with the staining solution for NADP-malate dehydrogenase (MOD) but differs from MOD. MDL-1 expresses three phenotypes: MDL-1A (fast), MDL-1AB (intermediate), and MDL-1B (slow). Progeny testing from genetic crosses indicates that its expression is determined by two codominant alleles, Mdl-1a and Mdl-1b, which segregate in a simple Mendelian fashion. Preliminary linkage data suggest that the locus for MDL-1 is probably linked to the nonagouti-agouti locus in rat linkage group IV.

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Year:  1982        PMID： 7115281     DOI： 10.1007/bf00484695

Source DB:  PubMed          Journal:  Biochem Genet        ISSN： 0006-2928            Impact factor:   1.890


  13 in total

1.  Serum esterase genetics in rats: two new alleles at Es-2, a new esterase regulated by hormonal factors, and linkage of these loci to the Ag-C blood group locus.

Authors:  D L Gasser; W K Silvers; H M Reynolds; G Black; J Palm
Journal:  Biochem Genet       Date:  1973-11       Impact factor: 1.890

2.  Isozymes and genetic control of NADP-malate dehydrogenase in mice.

Authors:  N S Henderson
Journal:  Arch Biochem Biophys       Date:  1966-10       Impact factor: 4.013

3.  Biochemical genetics of rat esterases: polymorphism, tissue expression, and linkage of four loci.

Authors:  J E Womack
Journal:  Biochem Genet       Date:  1973-05       Impact factor: 1.890

4.  Seminal vesicle protein in rats: a gene in the fourth linkage group determining electrophoretic variants.

Authors:  D L Gasser
Journal:  Biochem Genet       Date:  1972-02       Impact factor: 1.890

5.  Sub-unit structure of soluble and mitochondrial malic enzyme: demonstration of human mitochondrial enzyme in human-mouse hybrids.

Authors:  S Povey; D E Wilson; H Harris; I P Gormley; P Perry; K E Buckton
Journal:  Ann Hum Genet       Date:  1975-10       Impact factor: 1.670

6.  Comparative autosomal linkage in mammals: genetics of esterases in Mus musculus and Rattus norvegicus.

Authors:  J E Womack; M Sharp
Journal:  Genetics       Date:  1976-04       Impact factor: 4.562

7.  Evidence for linkage between four esterase loci in the rat (Rattus norvegicus).

Authors:  R Moutier; K Toyama; M F Charrier
Journal:  Biochem Genet       Date:  1973-06       Impact factor: 1.890

8.  Isolation and regulatory properties of mitochondrial malic enzyme from rat skeletal muscle.

Authors:  J Swierczyński; A Stankiewicz; P Scislowski; Z Aleksandrowicz
Journal:  Biochim Biophys Acta       Date:  1980-03-14

9.  Biochemical polymorphism in the rat, Rattus norvegicus: genetic study of four markers.

Authors:  R Moutier; K Toyama; M F Charrier
Journal:  Biochem Genet       Date:  1973-03       Impact factor: 1.890

10.  Linkage analyses among five esterase loci in the laboratory rat (Rattus norvegicus).

Authors:  J Yamada; H Nikaido; S Matsumoto
Journal:  Biochem Genet       Date:  1980-06       Impact factor: 1.890
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  3 in total

1.  Linkage of diabetes insipidus and agouti genes in the rat.

Authors:  V Stolc
Journal:  Biochem Genet       Date:  1984-10       Impact factor: 1.890

2.  Enzyme markers in inbred rat strains: genetics of new markers and strain profiles.

Authors:  M Adams; P R Baverstock; C H Watts; G A Gutman
Journal:  Biochem Genet       Date:  1984-08       Impact factor: 1.890

3.  A rat genetic linkage map and comparative maps for mouse or human homologous rat genes.

Authors:  J Yamada; T Kuramoto; T Serikawa
Journal:  Mamm Genome       Date:  1994-02       Impact factor: 2.957
  3 in total

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