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Literature DB >> 6517853

Linkage of diabetes insipidus and agouti genes in the rat.

Abstract

Linkage of the hooded (h), agouti (A), and diabetes insipidus (di) genes was found in (ACI X DI)F1 X DI backcross rats. The genetic map distance A-di for females and for males was 19 +/- 5 and 28 +/- 5 cM, respectively. However, this difference was not significant. The combined data showed the map distance to be 25 +/- 4 cM. The three-point cross showed the following corrected distances and order of genes: h-42 +/- 4-A-25 +/- 4-di. However, the linkage of h and A, although significant (chi 2 = 9.03, P less than 0.001), is only tentative and must be confirmed by additional studies.

Entities: Chemical Disease Species

Mesh：

Year: 1984 PMID： 6517853 DOI： 10.1007/bf00499480

Source DB: PubMed Journal: Biochem Genet ISSN： 0006-2928 Impact factor: 1.890

26 in total

8. Neurohypophysial principles in rats homozygous and heterozygous for hypothalamic diabetes insipidus (Brattleboro strain).

Authors: H Valtin; W H Sawyer; H W Sokol
Journal: Endocrinology Date: 1965-10 Impact factor: 4.736

9. Immuno-cytochemical demonstration of the inability of the homozygous Brattleboro rat to synthesize vasopressin and vasopressin-associated neurophysin.

Authors: F Vandesande; K Dierickx
Journal: Cell Tissue Res Date: 1976-01-27 Impact factor: 5.249

Linkage of diabetes insipidus and agouti genes in the rat.

1. Inherited hypothalamic diabetes insipidus in the Brattleboro strain of rats.

2. The hypothalamic median eminence of the homozygous Brattleboro rat is deficient in calcitonin-specific binding sites.

3. The discovery of the Brattleboro rat, recommended nomenclature, and the question of proper controls.

4. The linkage of glyoxylase-I to the major histocompatibility complex in the rat.

5. Influence of vasopressin upon firing patterns of supraoptic neurons: a comparison of normal and Brattleboro rats.

Review 6. Behavioral modification in Brattleboro rats due to vasopressin administration and neural transplantation.

Review 7. Neuropeptides in rat brain development.

8. Neurohypophysial principles in rats homozygous and heterozygous for hypothalamic diabetes insipidus (Brattleboro strain).

9. Immuno-cytochemical demonstration of the inability of the homozygous Brattleboro rat to synthesize vasopressin and vasopressin-associated neurophysin.

10. Linkage Studies of the Rat (Rattus Norvegicus).

1. Localization of the vasopressin gene to rat chromosome 3.

2. Localization in the fourth linkage group of a gene di affecting diabetes insipidus in rats.

3. A rat genetic linkage map and comparative maps for mouse or human homologous rat genes.