| Literature DB >> 71152 |
D E Woolley, M J Crossley, J M Evanson.
Abstract
Immunolocalization studies of rheumatoid tissues employing specific synovial collagenase antibody have demonstrated immunoreactive enzyme at the cartilage/pannus junction. Collagenase was not detected in chondrocytes or the cartilage matrix remote from the resorbing front, and relatively little enzyme was observed in the hypertrophied synovial membrane itself. These observations directly support the idea that synovial collagenase participates in cartilage erosion in rheumatoid arthritis.Entities:
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Year: 1977 PMID: 71152 DOI: 10.1002/art.1780200612
Source DB: PubMed Journal: Arthritis Rheum ISSN: 0004-3591