Renal cell carcinoma: two new cell lines and a serially transplantable nude mouse tumor (NC 65). Preliminary report.

Two long-term tissue culture cell lines and a serially transplantable tumor line growing on nude mice were obtained from a renal cell adenocarcinoma (NC 65). Results of the preliminary characterization of these tumor lines are presented. These data include tumor and cell morphology and growth characteristics in vivo and in vitro. In the nude mouse the tumor matastases to axillary and inguinal lymph nodes. The slow growth rates in culture and in the nude mice as well as the maintenance of the original histologic picture indicate that this tumor still reflects properties of the original carcinoma. Chromosomal analysis proves the human origin of the cell lines.