Literature DB >> 7109703

Human lymphocytes resistant to 6-thioguanine increase with age.

A A Morley, S Cox, R Holliday.   

Abstract

Using an autoradiographic technique we determined the number of circulating lymphocytes that were resistant to 6-thioguanine and which were presumably mutants at the hypoxanthine--guanine phosphoribosyl transferase locus. The number in normal individuals was found to increase exponentially with age. The data suggest a relationship between mutagenesis and ageing, perhaps by way of a decline with age in the fidelity of DNA replication or repair.

Entities:  

Mesh：

Substances：

Year:  1982        PMID： 7109703     DOI： 10.1016/0047-6374(82)90046-x

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN： 0047-6374            Impact factor:   5.432


  10 in total

1.  Influence of sex, smoking and age on human hprt mutation frequencies and spectra.

Authors:  J Curry; L Karnaoukhova; G C Guenette; B W Glickman
Journal:  Genetics       Date:  1999-07       Impact factor: 4.562

Review 2.  Somatic mutations in aging, cancer and neurodegeneration.

Authors:  Scott R Kennedy; Lawrence A Loeb; Alan J Herr
Journal:  Mech Ageing Dev       Date:  2011-11-03       Impact factor: 5.432

3.  The szilard hypothesis on the nature of aging revisited.

Authors:  Henrik Zetterberg; Magnus Båth; Madeleine Zetterberg; Peter Bernhardt; Ola Hammarsten
Journal:  Genetics       Date:  2009-05       Impact factor: 4.562

Review 4.  Genetic modifications during cellular aging.

Authors:  S Goldstein; R J Shmookler Reis
Journal:  Mol Cell Biochem       Date:  1984-09       Impact factor: 3.396

5.  Cytogerontology since 1881: a reappraisal of August Weismann and a review of modern progress.

Authors:  T B Kirkwood; T Cremer
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132

6.  Spontaneously arising red cells with a McLeod-like phenotype in normal donors.

Authors:  David J Araten; Katie J Sanders; Jeffrey Pu; Soohee Lee
Journal:  Mutat Res       Date:  2009-04-02       Impact factor: 2.433

7.  Elevated levels of somatic mutation in a manifesting BRCA1 mutation carrier.

Authors:  Stephen G Grant; Rubina Das; Christina M Cerceo; Wendy S Rubinstein; Jean J Latimer
Journal:  Pathol Oncol Res       Date:  2007-12-25       Impact factor: 3.201

8.  Age-associated decreases in human DNA repair capacity: Implications for the skin.

Authors:  I M Hadshiew; M S Eller; B A Gilchrest
Journal:  Age (Omaha)       Date:  1999-04

9.  Leukemic blasts with the paroxysmal nocturnal hemoglobinuria phenotype in children with acute lymphoblastic leukemia.

Authors:  David J Araten; Katie J Sanders; Dan Anscher; Leah Zamechek; Stephen P Hunger; Sherif Ibrahim
Journal:  Am J Pathol       Date:  2012-08-30       Impact factor: 4.307

Review 10.  Changes in DNA repair during aging.

Authors:  Vera Gorbunova; Andrei Seluanov; Zhiyong Mao; Christpher Hine
Journal:  Nucleic Acids Res       Date:  2007-10-02       Impact factor: 16.971
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.