Literature DB >> 6387441

Genetic modifications during cellular aging.

S Goldstein, R J Shmookler Reis.   

Abstract

We review evidence that biological aging is a genetic process related to development and cytodifferentiation and thus may involve alterations of DNA structure and gene expression. We conclude that although determined to a high degree aging also involves stochastic features which lead to progressive somatic cell diversification during the life span. These considerations may help to explain the unevenness of physiological decline and the clonal emergence of certain age-dependent diseases such as cancer.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6387441     DOI： 10.1007/bf00420924

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  93 in total

Review 1.  The regulation of physiological changes during mammalian aging.

Authors:  C E Finch
Journal:  Q Rev Biol       Date:  1976-03       Impact factor: 4.875

Review 2.  The ovalbumin gene: organization, structure, transcription, and regulation.

Authors:  B W O'Malley; D R Roop; E C Lai; J L Nordstrom; J F Catterall; G E Swaneck; D A Colbert; M J Tsai; A Dugaiczyk; S L Woo
Journal:  Recent Prog Horm Res       Date:  1979

Review 3.  The specificity of molecular hybridization reactions.

Authors:  B J McCarthy; R B Church
Journal:  Annu Rev Biochem       Date:  1970       Impact factor: 23.643

4.  The genetics of antibody diversity.

Authors:  P Leder
Journal:  Sci Am       Date:  1982-05       Impact factor: 2.142

Review 5.  5-Methylcytosine in eukaryotic DNA.

Authors:  M Ehrlich; R Y Wang
Journal:  Science       Date:  1981-06-19       Impact factor: 47.728

6.  Gene amplification in a single cell cycle in Chinese hamster ovary cells.

Authors:  B D Mariani; R T Schimke
Journal:  J Biol Chem       Date:  1984-02-10       Impact factor: 5.157

7.  On the role of aging in cancer incidence.

Authors:  D Dix; P Cohen; J Flannery
Journal:  J Theor Biol       Date:  1980-03-07       Impact factor: 2.691

8.  Differential regulation of the messenger RNA for three major senescence marker proteins in male rat liver.

Authors:  B Chatterjee; T S Nath; A K Roy
Journal:  J Biol Chem       Date:  1981-06-25       Impact factor: 5.157

9.  Evidence for endogenous polypeptide-mediated inhibition of cell-cycle transit in human diploid cells.

Authors:  G C Burmer; C J Zeigler; T H Norwood
Journal:  J Cell Biol       Date:  1982-07       Impact factor: 10.539

10.  Status of mitochondria in living human fibroblasts during growth and senescence in vitro: use of the laser dye rhodamine 123.

Authors:  S Goldstein; L B Korczack
Journal:  J Cell Biol       Date:  1981-11       Impact factor: 10.539
View more
  4 in total

Review 1.  Regulation of mRNA polyadenylation-deadenylation.

Authors:  C M Tsiapalis
Journal:  Mol Biol Rep       Date:  1987       Impact factor: 2.316

2.  Loss of expression of a differentiated function gene, steroid 17 alpha-hydroxylase, as adrenocortical cells senescence in culture.

Authors:  P J Hornsby; J P Hancock; T P Vo; L M Nason; R F Ryan; J M McAllister
Journal:  Proc Natl Acad Sci U S A       Date:  1987-03       Impact factor: 11.205

3.  Frequency of 6-thioguanine-resistant T cells is inversely related to the declining T-cell activities in aging mice.

Authors:  T Inamizu; N Kinohara; M P Chang; T Makinodan
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

4.  Specific growth inhibitory sequences in genomic DNA from quiescent human embryo fibroblasts.

Authors:  R Padmanabhan; T H Howard; B H Howard
Journal:  Mol Cell Biol       Date:  1987-05       Impact factor: 4.272
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.