Literature DB >> 7107609

In vitro vinblastine-induced tubulin paracrystals.

G C Na, S N Timasheff.   

Abstract

Purified calf brain tubulin has been induced to self-aggregate in vitro into paracrystalline structures by the anti-cancer drug vinblastine. The size, shape, optical birefringence, and drug stoichiometry of these tubulin-vinblastine paracrystals are similar to those of paracrystals formed in vivo. Similar structures can be formed with vincristine and desacetylvinblastine, but not with colchicine or podophyllotoxin.

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Year:  1982        PMID： 7107609

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  9 in total

1.  Fluorescent vinblastine probes for live cell imaging.

Authors:  Labros G Meimetis; Randy J Giedt; Hannes Mikula; Jonathan C Carlson; Rainer H Kohler; David B Pirovich; Ralph Weissleder
Journal:  Chem Commun (Camb)       Date:  2016-08-02       Impact factor: 6.222

2.  Effect of the antitumor drug vinblastine on nuclear betaII-tubulin in cultured rat kidney mesangial cells.

Authors:  Consuelo Walss-Bass; Jeffrey I Kreisberg; Richard F Ludueña
Journal:  Invest New Drugs       Date:  2003-02       Impact factor: 3.850

3.  Serge Timasheff: the man with a genius for solutions in biology.

Authors:  J A Schellman; G N Somero
Journal:  Biophys J       Date:  1996-10       Impact factor: 4.033

4.  Sodium current modulation by a tubulin/GTP coupled process in rat neonatal cardiac myocytes.

Authors:  Delara Motlagh; Kris J Alden; Brenda Russell; Jesús García
Journal:  J Physiol       Date:  2002-04-01       Impact factor: 5.182

5.  Differential in vitro action of S-12363, a new vinblastine derivative, and of its epimer on microtubule proteins.

Authors:  M Wright; M Garès; P Verdier-Pinard; A Moisand; M Berlion; J J Legrand; J P Bizzari
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333

6.  Vinblastine suppresses dynamics of individual microtubules in living interphase cells.

Authors:  R Dhamodharan; M A Jordan; D Thrower; L Wilson; P Wadsworth
Journal:  Mol Biol Cell       Date:  1995-09       Impact factor: 4.138

7.  In vitro formation of the endoplasmic reticulum occurs independently of microtubules by a controlled fusion reaction.

Authors:  L Dreier; T A Rapoport
Journal:  J Cell Biol       Date:  2000-03-06       Impact factor: 10.539

8.  Kinetically Stabilizing Mutations in Beta Tubulins Create Isotype-Specific Brain Malformations.

Authors:  Kristen Park; Katelyn J Hoff; Linnea Wethekam; Nicholas Stence; Margarita Saenz; Jeffrey K Moore
Journal:  Front Cell Dev Biol       Date:  2021-11-18

9.  S-phase specificity of cell killing by docetaxel (Taxotere) in synchronised HeLa cells.

Authors:  C Hennequin; N Giocanti; V Favaudon
Journal:  Br J Cancer       Date:  1995-06       Impact factor: 7.640
  9 in total

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