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Literature DB >> 7102676

Two previously undetected variants of glutamic-pyruvic transaminase found by acidic polyacrylamide gel electrophoresis.

Abstract

Two new electrophoretic variants of glutamic-pyruvic transaminase (GPT) have been found by polyacrylamide gel electrophoresis at acidic pH. They appeared to represent a single allele, GPT 2, by the standard method of starch gel electrophoresis. Studies in families show that they are inherited as codominant alleles at the GPT locus. Population frequencies are about the same as those of other rare GPT variants. Their behavior on gels is consistent with both of them having substitutions of histidines in place of uncharged amino acids.

Entities: Chemical Gene

Mesh：

Substances：
Alanine Transaminase

Year: 1982 PMID： 7102676 PMCID： PMC1685356

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

9 in total

1. Breast cancer in one family group.

Authors: E J GARDNER; F E STEPHENS
Journal: Am J Hum Genet Date: 1950-03 Impact factor: 11.025

2. The distribution of isoelectric points of human soluble proteins and in particular of the enzyme products of 88 human gene loci.

Authors: R A Fisher; W Putt; H Harris
Journal: Ann Hum Genet Date: 1977-05 Impact factor: 1.670

3. The detection of hexokinase, glucosephosphate isomerase and phosphoglucomutase activities in polyacrylamide gels after electrophoresis: a novel method using immobilized glucose 6-phosphate dehydrogenase.

Authors: R A Harrison
Journal: Anal Biochem Date: 1974-10 Impact factor: 3.365

4. Genetics of glutamic-pyruvic transaminase: its inheritance, common and rare variants, population distribution, and differences in catalytic activity.

Authors: S H Chen; E R Giblett; J E Anderson; B L Fossum
Journal: Ann Hum Genet Date: 1972-04 Impact factor: 1.670

4 in total

Two previously undetected variants of glutamic-pyruvic transaminase found by acidic polyacrylamide gel electrophoresis.

1. Breast cancer in one family group.

2. The distribution of isoelectric points of human soluble proteins and in particular of the enzyme products of 88 human gene loci.

3. The detection of hexokinase, glucosephosphate isomerase and phosphoglucomutase activities in polyacrylamide gels after electrophoresis: a novel method using immobilized glucose 6-phosphate dehydrogenase.

4. Genetics of glutamic-pyruvic transaminase: its inheritance, common and rare variants, population distribution, and differences in catalytic activity.

5. The sensitivity of gel electrophoresis as a detector of genetic variation.

6. Hereditary hemochromatosis. Phenotypic expression of the disease.

7. Polymorphism of soluble glutamic-pyruvic transaminase: a new genetic marker in man.

8. Genetic linkage between hereditary hemochromatosis and HLA.

9. Polymorphism of alanine aminotransferase (E.C.2.7.6.1): common and rare alleles.

1. The sensitivity of isoelectric focusing and electrophoresis in the detection of sequence differences in proteins.

2. Genetic distances between the Utah Mormons and related populations.

3. Identification of human red cell glutamate-pyruvate transaminase (GPT) phenotypes by isoelectric focusing.

4. Molecular charge and electrophoretic mobility in cetacean myoglobins of known sequence.