Literature DB >> 7100920

Psoralen phototoxicity: correlation with serum and epidermal 8-methoxypsoralen and 5-methoxypsoralen in the guinea pig.

A Kornhauser, W G Wamer, A L Giles.   

Abstract

Serum and epidermal concentrations of 8-methoxypsoralen and 5-methoxypsoralen 2 hours after oral administration to guinea pigs were determined by high-performance liquid chromatography. A linear relation was found between the serum and epidermal concentrations of 8-methoxypsoralen. In addition, a relation was found between serum concentrations of 5-methoxypsoralen and 8-methoxypsoralen and the appearance of phototoxicity. The lower phototoxicity of orally administered 5-methoxypsoralen as compared to 8-methoxypsoralen in the guinea pig appears to be due to its reduced concentrations in the epidermis, the primary site of the phototoxic events.

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Year:  1982        PMID： 7100920     DOI： 10.1126/science.7100920

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  6 in total

1.  Citrus Consumption and Risk of Cutaneous Malignant Melanoma.

Authors:  Shaowei Wu; Jiali Han; Diane Feskanich; Eunyoung Cho; Meir J Stampfer; Walter C Willett; Abrar A Qureshi
Journal:  J Clin Oncol       Date:  2015-06-29       Impact factor: 44.544

2.  Safety and efficacy of feed additives consisting of expressed lemon oil and its fractions from Citrus limon (L.) Osbeck and of lime oil from Citrus aurantiifolia (Christm.) Swingle for use in all animal species (FEFANA asbl).

Authors:  Vasileios Bampidis; Giovanna Azimonti; Maria de Lourdes Bastos; Henrik Christensen; Maryline Kouba; Mojca Fašmon Durjava; Marta López-Alonso; Secundino López Puente; Francesca Marcon; Baltasar Mayo; Alena Pechová; Mariana Petkova; Fernando Ramos; Yolanda Sanz; Roberto Edoardo Villa; Ruud Woutersen; Paul Brantom; Andrew Chesson; Johannes Westendorf; Jaume Galobart; Paola Manini; Fabiola Pizzo; Birgit Dusemund
Journal:  EFSA J       Date:  2021-04-30

3.  Citrus consumption and risk of basal cell carcinoma and squamous cell carcinoma of the skin.

Authors:  Shaowei Wu; Eunyoung Cho; Diane Feskanich; Wen-Qing Li; Qi Sun; Jiali Han; Abrar A Qureshi
Journal:  Carcinogenesis       Date:  2015-07-29       Impact factor: 4.944

4.  Treatment of psoriasis with a new micronized 5-methoxypsoralen tablet and UVA radiation.

Authors:  F Aubin; S Makki; P Humbert; P Muret; P Agache
Journal:  Arch Dermatol Res       Date:  1994       Impact factor: 3.017

5.  Intake of Furocoumarins and Risk of Skin Cancer in 2 Prospective US Cohort Studies.

Authors:  Weiyi Sun; Megan S Rice; Min K Park; Ock K Chun; Melissa M Melough; Hongmei Nan; Walter C Willett; Wen-Qing Li; Abrar A Qureshi; Eunyoung Cho
Journal:  J Nutr       Date:  2020-06-01       Impact factor: 4.798

6.  Association between Citrus Consumption and Melanoma Risk in the NIH-AARP Diet and Health Study.

Authors:  Melissa M Melough; Junichi Sakaki; Linda M Liao; Rashmi Sinha; Eunyoung Cho; Ock K Chun
Journal:  Nutr Cancer       Date:  2020-08-13       Impact factor: 2.900
  6 in total

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