Literature DB >> 33968248

Safety and efficacy of feed additives consisting of expressed lemon oil and its fractions from Citrus limon (L.) Osbeck and of lime oil from Citrus aurantiifolia (Christm.) Swingle for use in all animal species (FEFANA asbl).

Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Maryline Kouba, Mojca Fašmon Durjava, Marta López-Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Paul Brantom, Andrew Chesson, Johannes Westendorf, Jaume Galobart, Paola Manini, Fabiola Pizzo, Birgit Dusemund.   

Abstract

Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of expressed lemon oil and distilled lemon oil from Citrus limon (L.) Osbeck and lime oil from Citrus aurantiifolia (Christm.) Swingle, when used as sensory additives in feed for all animal species. The use of the expressed lemon oil and its residual fraction and the use of lime oil in feed is not expected to increase the exposure to furocoumarins and methoxycoumarins and perillaldehyde of those target species that are already fed citrus by-products a relevant extent (< 10%). For companion animals and ornamental fish not normally exposed to citrus by-products, no conclusion can be drawn. For the other species and for the distilled fraction of expressed lemon oil, the FEEDAP Panel concludes that the additives under assessment are safe at the maximum proposed or at reduced use levels in complete feed. The Panel considers that the use in water for drinking is safe provided that the total daily intake of the additive does not exceed the daily amount that is considered safe when consumed via feed. No concerns for consumer safety were identified following the use of the additives at the maximum proposed use level in feed. The additives under assessment should be considered as irritants to skin and eyes and the respiratory tract and as skin sensitisers. Since expressed lemon oil and its fractions contain furocoumarins, they may cause phototoxicity. The use of the additives under the proposed conditions of use in animal feed is not expected to pose a risk for the environment. Since C. limon and C. aurantiifolia and their preparations are recognised to flavour food and its function in feed would be essentially the same as that in food, no further demonstration of efficacy is considered necessary.
© 2021 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.

Entities:  

Keywords:  Citrus aurantiifolia (Christm.) Swingle; Citrus limon (L.) Osbeck; component‐based approach; flavouring compounds; furocoumarins; perillaldehyde; sensory additives

Year:  2021        PMID: 33968248      PMCID: PMC8085978          DOI: 10.2903/j.efsa.2021.6548

Source DB:  PubMed          Journal:  EFSA J        ISSN: 1831-4732


  36 in total

1.  Guidance on harmonised methodologies for human health, animal health and ecological risk assessment of combined exposure to multiple chemicals.

Authors:  Simon John More; Vasileios Bampidis; Diane Benford; Susanne Hougaard Bennekou; Claude Bragard; Thorhallur Ingi Halldorsson; Antonio F Hernández-Jerez; Konstantinos Koutsoumanis; Hanspeter Naegeli; Josef R Schlatter; Vittorio Silano; Søren Saxmose Nielsen; Dieter Schrenk; Dominique Turck; Maged Younes; Emilio Benfenati; Laurence Castle; Nina Cedergreen; Anthony Hardy; Ryszard Laskowski; Jean Charles Leblanc; Andreas Kortenkamp; Ad Ragas; Leo Posthuma; Claus Svendsen; Roland Solecki; Emanuela Testai; Bruno Dujardin; George En Kass; Paola Manini; Maryam Zare Jeddi; Jean-Lou Cm Dorne; Christer Hogstrand
Journal:  EFSA J       Date:  2019-03-25

2.  Quantitative evaluation of auraptene and umbelliferone, chemopreventive coumarins in citrus fruits, by HPLC-UV-FL-MS.

Authors:  Laura Mercolini; Roberto Mandrioli; Anna Ferranti; Vittorio Sorella; Michele Protti; Francesco Epifano; Massimo Curini; Maria Augusta Raggi
Journal:  J Agric Food Chem       Date:  2012-10-29       Impact factor: 5.279

Review 3.  Dietary furocoumarins and skin cancer: A review of current biological evidence.

Authors:  Melissa M Melough; Ock K Chun
Journal:  Food Chem Toxicol       Date:  2018-10-11       Impact factor: 6.023

4.  Repeated-doses and reproductive toxicity studies of the monoterpene 1,8-cineole (eucalyptol) in Wistar rats.

Authors:  Germana Freire Rocha Caldas; Mayara Marília Ferreira Limeira; Alice Valença Araújo; Giwellington Silva Albuquerque; Jacinto da Costa Silva-Neto; Teresinha Gonçalves da Silva; João Henrique Costa-Silva; Irwin Rose Alencar de Menezes; José Galberto Martins da Costa; Almir Gonçalves Wanderley
Journal:  Food Chem Toxicol       Date:  2016-09-16       Impact factor: 6.023

5.  Identification of coumarins from lemon fruit (Citrus limon) as inhibitors of in vitro tumor promotion and superoxide and nitric oxide generation.

Authors:  Y Miyake; A Murakami; Y Sugiyama; M Isobe; K Koshimizu; H Ohigashi
Journal:  J Agric Food Chem       Date:  1999-08       Impact factor: 5.279

6.  Modulation of flavanone and furocoumarin levels in grapefruits (Citrus paradisi Macfad.) by production and storage conditions.

Authors:  Kranthi K Chebrolu; J Jifon; Bhimanagouda S Patil
Journal:  Food Chem       Date:  2015-09-10       Impact factor: 7.514

7.  Coumarins from the peel of citrus grown in Colombia: composition, elicitation and antifungal activity.

Authors:  Cesar Ramírez-Pelayo; Janio Martínez-Quiñones; Jesús Gil; Diego Durango
Journal:  Heliyon       Date:  2019-06-15

8.  Guidance on the use of the Threshold of Toxicological Concern approach in food safety assessment.

Authors:  Simon J More; Vasileios Bampidis; Diane Benford; Claude Bragard; Thorhallur I Halldorsson; Antonio F Hernández-Jerez; Susanne Hougaard Bennekou; Kostas P Koutsoumanis; Kyriaki Machera; Hanspeter Naegeli; Søren S Nielsen; Josef R Schlatter; Dieter Schrenk; Vittorio Silano; Dominique Turck; Maged Younes; Ursula Gundert-Remy; George E N Kass; Juliane Kleiner; Anna Maria Rossi; Rositsa Serafimova; Linda Reilly; Heather M Wallace
Journal:  EFSA J       Date:  2019-06-06

9.  Guidance on the assessment of the safety of feed additives for the consumer.

Authors:  Guido Rychen; Gabriele Aquilina; Giovanna Azimonti; Vasileios Bampidis; Maria de Lourdes Bastos; Georges Bories; Andrew Chesson; Pier Sandro Cocconcelli; Gerhard Flachowsky; Jürgen Gropp; Boris Kolar; Maryline Kouba; Marta López-Alonso; Secundino López Puente; Alberto Mantovani; Baltasar Mayo; Fernando Ramos; Maria Saarela; Roberto Edoardo Villa; Robert John Wallace; Pieter Wester; Montserrat Anguita; Bruno Dujardin; Jaume Galobart; Matteo Lorenzo Innocenti
Journal:  EFSA J       Date:  2017-10-17

10.  Genotoxicity assessment of chemical mixtures.

Authors:  Simon More; Vasileios Bampidis; Diane Benford; Jos Boesten; Claude Bragard; Thorhallur Halldorsson; Antonio Hernandez-Jerez; Susanne Hougaard-Bennekou; Kostas Koutsoumanis; Hanspeter Naegeli; Søren Saxmose Nielsen; Dieter Schrenk; Vittorio Silano; Dominique Turck; Maged Younes; Gabriele Aquilina; Riccardo Crebelli; Rainer Gürtler; Karen Ildico Hirsch-Ernst; Pasquale Mosesso; Elsa Nielsen; Roland Solecki; Maria Carfì; Carla Martino; Daniela Maurici; Juan Parra Morte; Josef Schlatter
Journal:  EFSA J       Date:  2018-12-18
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1.  Safety and efficacy of a feed additive consisting of an essential oil from the flowers of Cananga odorata (Lam.) Hook.f. & Thomson (ylang ylang oil) for use in all animal species (FEFANA asbl).

Authors:  Vasileios Bampidis; Giovanna Azimonti; Maria de Lourdes Bastos; Henrik Christensen; Mojca Fašmon Durjava; Maryline Kouba; Marta López-Alonso; Secundino López Puente; Francesca Marcon; Baltasar Mayo; Alena Pechová; Mariana Petkova; Fernando Ramos; Yolanda Sanz; Roberto Edoardo Villa; Ruud Woutersen; Paul Brantom; Andrew Chesson; Johannes Westendorf; Paola Manini; Fabiola Pizzo; Birgit Dusemund
Journal:  EFSA J       Date:  2022-02-24

2.  Safety and efficacy of a feed additive consisting of an essential oil from the leaves of Agathosma betulina (P.J. Bergius) Pillans (buchu leaf oil) for use in all animal species (FEFANA asbl).

Authors:  Vasileios Bampidis; Giovanna Azimonti; Maria de Lourdes Bastos; Henrik Christensen; Mojca Fašmon Durjava; Maryline Kouba; Marta López-Alonso; Secundino López Puente; Francesca Marcon; Baltasar Mayo; Alena Pechová; Mariana Petkova; Fernando Ramos; Yolanda Sanz; Roberto Edoardo Villa; Ruud Woutersen; Paul Brantom; Andrew Chesson; Johannes Westendorf; Paola Manini; Fabiola Pizzo; Birgit Dusemund
Journal:  EFSA J       Date:  2022-03-08

3.  Safety and efficacy of a feed additive consisting of an essential oil from Cinnamomum camphora (L.) J. Presl (camphor white oil) for use in all animal species (FEFANA asbl).

Authors:  Vasileios Bampidis; Giovanna Azimonti; Maria de Lourdes Bastos; Henrik Christensen; Mojca Fašmon Durjava; Maryline Kouba; Marta López-Alonso; Secundino López Puente; Francesca Marcon; Baltasar Mayo; Alena Pechová; Mariana Petkova; Fernando Ramos; Yolanda Sanz; Roberto Edoardo Villa; Ruud Woutersen; Paul Brantom; Andrew Chesson; Johannes Westendorf; Paola Manini; Fabiola Pizzo; Birgit Dusemund
Journal:  EFSA J       Date:  2022-01-13

4.  Safety and efficacy of a feed additive consisting of a flavonoid-rich dried extract of Citrus × aurantium L. fruit (bitter orange extract) for use in all animal species (FEFANA asbl).

Authors:  Vasileios Bampidis; Giovanna Azimonti; Maria de Lourdes Bastos; Henrik Christensen; Mojca Fašmon Durjava; Maryline Kouba; Marta López-Alonso; Secundino López Puente; Francesca Marcon; Baltasar Mayo; Alena Pechová; Mariana Petkova; Fernando Ramos; Yolanda Sanz; Roberto Edoardo Villa; Ruud Woutersen; Paul Brantom; Andrew Chesson; Johannes Westendorf; Paola Manini; Fabiola Pizzo; Birgit Dusemund
Journal:  EFSA J       Date:  2021-07-27
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