Literature DB >> 70988

Liberation of endogenous compounds by tolazoline.

M J Hughes, L J O'Brien.   

Abstract

The anomalous cardiac stimulation by tolazoline (2-benzyl-2-imidazoline), and alpha-adrenergic blocking agent, appears to result from the release of histamine and catecholamines. These responses can be blocked by metiamide and propranolol, respectively. It is probably that tolazoline also releases acetylcholine from the guinea pig atria. The direct effect of tolazoline on chronotropic activity of atrial pairs after blockade appears to be depressant at high concentrations, and this decrease in rate, below control levels, is not blocked by atropine.

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Year:  1977        PMID： 70988     DOI： 10.1007/BF01969977

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  14 in total

1.  Basophil leucocytes and mast cells in the rabbit before and after intravenous injection of compound 48/80.

Authors:  T E HUNT; E A HUNT; D CURRY
Journal:  Anat Rec       Date:  1961-06

2.  The release of histamine by pethidine, atropine, quinine, and other drugs.

Authors:  M SCHACHTER
Journal:  Br J Pharmacol Chemother       Date:  1952-12

3.  Comparison of the effects of histamine and tolazoline on adenylate cyclase activity from guinea pig heart.

Authors:  I Weinryb; I M Michel
Journal:  J Med Chem       Date:  1975-01       Impact factor: 7.446

4.  A Quantitative study of histamine H2-receptor bockade by burimamide in isolated artica.

Authors:  M J Hughes; I A Coret
Journal:  Proc Soc Exp Biol Med       Date:  1975-01

5.  A phylogenetic study on the occurrence and distribution of histamine in the gastro-intestinal tract and other tissues of man and various animals.

Authors:  W Lorenz; E Matejka; A Schmal; W Seidel; H J Reimann; R Uhlig; G Mann
Journal:  Comp Gen Pharmacol       Date:  1973-09

6.  Effects of tricyclic compounds on the histamine response of isolated atria.

Authors:  M J Hughes; I A Coret
Journal:  J Pharmacol Exp Ther       Date:  1974-11       Impact factor: 4.030

7.  A quantitative description of chronotropic effects of histamine on rabbit heart.

Authors:  I A Coret; M J Hughes
Journal:  Arch Int Pharmacodyn Ther       Date:  1974-03

8.  On specificity of histamine receptors in the heart.

Authors:  M J Hughes; I A Coret
Journal:  Am J Physiol       Date:  1972-11

9.  Adrenolytic and sympatholytic actions of priscol (benzyl-imidazoline).

Authors:  D CHESS; F F YONKMAN
Journal:  Proc Soc Exp Biol Med       Date:  1946-02

10.  Anaphylaxis in the guinea-pig isolated heart: selective inhibition by burimamide of the positive inotropic and chronotropic effects of released histamine.

Authors:  N Capurro; R Levi
Journal:  Br J Pharmacol       Date:  1973-08       Impact factor: 8.739
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  2 in total

1.  Treatment of persistent fetal circulation syndrome of the newborn. Comparison of different doses of tolazoline.

Authors:  P Monin; C Dubruc; P Vert; P L Morselli
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

2.  Liberation of histamine by compound 48/80, tolazoline, betahistine and burimamide from isolated spontaneously beating guinea pig and rabbit atrial pairs.

Authors:  K E Light; M J Hughes
Journal:  Agents Actions       Date:  1979-06
  2 in total

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