Literature DB >> 89803

Liberation of histamine by compound 48/80, tolazoline, betahistine and burimamide from isolated spontaneously beating guinea pig and rabbit atrial pairs.

K E Light, M J Hughes.   

Abstract

Tolazoline, betahistine, burimamide and compound 48/80 release histamine from isolated guinea pig atria resulting in histamine concentrations that stimulate H2-receptors. Tolazoline, burimamide and 48/80 also release histamine from rabbit atria but do not result in histamine concentrations that will stimulate either H1- or H2-receptors. However, betahistine (which does not release histamine from rabbit atria) and tolazoline stimulate the rabbit atrial chronotropic response by releasing catecholamines.

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Year:  1979        PMID： 89803     DOI： 10.1007/BF02024725

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  22 in total

1.  Basophil leucocytes and mast cells in the rabbit before and after intravenous injection of compound 48/80.

Authors:  T E HUNT; E A HUNT; D CURRY
Journal:  Anat Rec       Date:  1961-06

2.  Mast cells and susceptibility to experimental atherosclerosis.

Authors:  P CONSTANTINIDES
Journal:  Science       Date:  1953-05-08       Impact factor: 47.728

3.  A comparison of the effects of anaphylactic shock and of chemical histamine releasers.

Authors:  J L MONGAR; H O SCHILD
Journal:  J Physiol       Date:  1952-12       Impact factor: 5.182

4.  Comparison of the effects of histamine and tolazoline on the inotropic, chronotropic and cyclic AMP producing effects in the guinea pig heart.

Authors:  S C Verma; J H McNeill
Journal:  Proc West Pharmacol Soc       Date:  1977

5.  A phylogenetic study on the occurrence and distribution of histamine in the gastro-intestinal tract and other tissues of man and various animals.

Authors:  W Lorenz; E Matejka; A Schmal; W Seidel; H J Reimann; R Uhlig; G Mann
Journal:  Comp Gen Pharmacol       Date:  1973-09

6.  Definition and antagonism of histamine H 2 -receptors.

Authors:  J W Black; W A Duncan; C J Durant; C R Ganellin; E M Parsons
Journal:  Nature       Date:  1972-04-21       Impact factor: 49.962

7.  A nonhistaminic response of rabbit atria to betahistine.

Authors:  M J Hughes
Journal:  J Clin Pharmacol       Date:  1977-01       Impact factor: 3.126

8.  Blockade by burimamide of the effects of histamine and histamine analogs on cardiac contractility, phosphorylase activation and cyclic adenosine monophosphate.

Authors:  J H McNeill; S C Verma
Journal:  J Pharmacol Exp Ther       Date:  1974-01       Impact factor: 4.030

9.  A sensitive and specific method for the determination of histomine in human whole blood and plasma.

Authors:  W Lorenz; H J Reimann; H Barth; J Kusche; R Meyer; A Doenicke; M Hutzel
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1972-06

10.  Uptake, disposition and metabolism of histamine in isolated heart preparations.

Authors:  P F Mannaioni; F Moroni
Journal:  Br J Pharmacol       Date:  1973-11       Impact factor: 8.739
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  3 in total

1.  Some studies of the action of betahistine at H1 and H2 receptors for histamine.

Authors:  P R Gater; S E Webber; G P Gui; C C Jordan; N A Hayes; J J Ashford; J C Foreman
Journal:  Agents Actions       Date:  1986-06

2.  The effects of cimetidine on histamine atrial chronotropic receptor activity.

Authors:  M J Hughes
Journal:  Agents Actions       Date:  1982-10

3.  Modification of isolated atrial chronotropic histamine receptor responses by alterations in the calcium concentration of the bathing medium.

Authors:  M J Hughes
Journal:  Agents Actions       Date:  1983-06
  3 in total

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