Literature DB >> 7093814

Cell mediated immune response in miniature Sinclair swine bearing cutaneous melanomas.

D H Jones, M S Amoss.   

Abstract

Miniature Sinclair swine bearing cutaneous melanomas and nonmelanoma bearing littermate controls were tested for lymphocyte blastogenic response in a microculture assay. Lymphocytes were assayed for 3H-thymidine incorporation following stimulation with concanavalin A, phytohemagglutinin or pokeweed mitogen. Treatment with all mitogens revealed a significantly (p less than 0.05) reduced proliferative capacity in melanoma swine as compared to littermate controls. These results lend further support for the use of miniature Sinclair swine as a research model for human melanoma.

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Year:  1982        PMID： 7093814      PMCID： PMC1320283     

Source DB:  PubMed          Journal:  Can J Comp Med        ISSN： 0008-4050


  18 in total

1.  [Immunologic reaction-readiness in malignant melanoma].

Authors:  R Bickhardt; J Kunze
Journal:  Z Hautkr       Date:  1974-04-15

2.  Cutaneous melanoma in miniature swine.

Authors:  A C Strafuss; A R Dommert; M E Tumbleson; C C Middleton
Journal:  Lab Anim Care       Date:  1968-04

3.  Melanotic lesions in the internal organs of miniature swine.

Authors:  R E Flatt; L R Nelson; C C Middleton
Journal:  Arch Pathol       Date:  1972-01

4.  Correlation of in vivo and in vitro assays of immunocompetence in cancer patients.

Authors:  S H Golub; T X O'Connell; D L Morton
Journal:  Cancer Res       Date:  1974-08       Impact factor: 12.701

5.  Melanoma in Sinclair swine: a new animal model.

Authors:  L E Millikan; J L Boylon; R R Hook; P J Manning
Journal:  J Invest Dermatol       Date:  1974-01       Impact factor: 8.551

6.  Pathogenesis of benign cutaneous melanomas in miniature swine.

Authors:  R E Flatt; C C Middleton; M E Tumbleson; C Perez-Mesa
Journal:  J Am Vet Med Assoc       Date:  1968-10-01       Impact factor: 1.936

7.  Biological aspects of human malignant melanoma.

Authors:  L Nathanson; T C Hall; S Farber
Journal:  Cancer       Date:  1967-05       Impact factor: 6.860

8.  Humoral and cell-mediated immune response in patients with malignant melanoma. I. In vitro lymphocyte reactivity to PHA and antigens following immunization.

Authors:  G C de Gast; T H The; H Schraffordt Koops; H A Huiges; J Oldhoff; H O Nieweg
Journal:  Cancer       Date:  1975-10       Impact factor: 6.860

9.  Lymphocyte reactivity in cancer patients: correlation with tumor histology and clinical stage.

Authors:  W J Catalona; W F Sample; P B Chretien
Journal:  Cancer       Date:  1973-01       Impact factor: 6.860

10.  Immunologic studies in patients with malignant melanoma in Uganda.

Authors:  J L Ziegler; M G Lewis; J M Luyombya; J W Kiryabwire
Journal:  Br J Cancer       Date:  1969-12       Impact factor: 7.640
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  1 in total

1.  Genetic determinants of cutaneous malignant melanoma in Sinclair swine.

Authors:  J Blangero; R G Tissot; C W Beattie; M S Amoss
Journal:  Br J Cancer       Date:  1996-03       Impact factor: 7.640
  1 in total

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