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Literature DB >> 8605105

Genetic determinants of cutaneous malignant melanoma in Sinclair swine.

J Blangero¹, R G Tissot, C W Beattie, M S Amoss.

Abstract

The role of genetic factors involved in the determination of risk of cutaneous malignant melanoma (CMM) in humans remains unclear owing to genetic heterogeneity and reliance on simplistic models of inheritance. Here, we report a statistical genetic analysis of cutaneous malignant melanoma in Sinclair swine (SSCM), a unique animal model for human CMM. Using complex segregation analysis a two-locus model involving an unknown major locus and a second locus that lies within or close to the swine leukocyte antigen (SLA) complex jointly determine risk of SSCM in pedigreed animals. These loci also influence severity of affection, accounting for approximately 20% of the phenotypic variation in quantitative tumour burden.

Entities: Disease Gene Species

Mesh：

Year: 1996 PMID： 8605105 PMCID： PMC2074359 DOI： 10.1038/bjc.1996.116

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

24 in total

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Journal: Epidemiol Rev Date: 1989 Impact factor: 6.222

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Journal: N Engl J Med Date: 1990-03-22 Impact factor: 91.245

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Authors: S J Hasstedt; P P Moll
Journal: Genet Epidemiol Date: 1989 Impact factor: 2.135

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Authors: S J Bale; N C Dracopoli; M A Tucker; W H Clark; M C Fraser; B Z Stanger; P Green; H Donis-Keller; D E Housman; M H Greene
Journal: N Engl J Med Date: 1989-05-25 Impact factor: 91.245

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Authors: G E Bonney
Journal: Biometrics Date: 1986-09 Impact factor: 2.571

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Authors: M H Greene; L R Goldin; W H Clark; E Lovrien; K H Kraemer; M A Tucker; D E Elder; M C Fraser; S Rowe
Journal: Proc Natl Acad Sci U S A Date: 1983-10 Impact factor: 11.205

7. The swine leucocyte antigen (SLA) complex and Sinclair swine cutaneous malignant melanoma.

Authors: R G Tissot; C W Beattie; M S Amoss
Journal: Anim Genet Date: 1989 Impact factor: 3.169

8. Cell-mediated immune reactivity of Sinclair melanoma-bearing swine to 3 M KCl extracts of swine and human melanoma.

Authors: R R Hook; C V Hamby; L E Millikan; J Berkelhammer; H F Stills; R W Oxenhandler
Journal: Int J Cancer Date: 1983-05-15 Impact factor: 7.396

9. Inheritance of Sinclair swine cutaneous malignant melanoma.

Authors: R G Tissot; C W Beattie; M S Amoss
Journal: Cancer Res Date: 1987-11-01 Impact factor: 12.701

10. Cutaneous malignant melanoma and familial dysplastic nevi: evidence for autosomal dominance and pleiotropy.

Authors: S J Bale; A Chakravarti; M H Greene
Journal: Am J Hum Genet Date: 1986-02 Impact factor: 11.025

6 in total

1. Genetic polymorphism of the swine major histocompatibility complex ( SLA) class I genes, SLA-1, -2 and -3.

Authors: Asako Ando; Hisako Kawata; Atsuko Shigenari; Tatsuya Anzai; Masao Ota; Yoshihiko Katsuyama; Masaharu Sada; Rieko Goto; Shin-Nosuke Takeshima; Yoko Aida; Takahiro Iwanaga; Nobuyuki Fujimura; Yoshiyuki Suzuki; Takashi Gojobori; Hidetoshi Inoko
Journal: Immunogenetics Date: 2003-11-07 Impact factor: 2.846