| Literature DB >> 7089997 |
C P Siegers, O Strubelt, E Dost-Kempf.
Abstract
Exposure of fed and fasted rats to CC1(4) vapor (114 ppm) for 6 h in a closed system increased serum enzyme activities (GOT, GPT, SDH) only in fasted animals. The in vivo metabolism of CC1(4), studied in the same system, was accelerated by fasting; the half-life of the elimination phase being reduced by approx. 33%. The enhanced susceptibility to CC1(4) induced by fasting seemed to be due to the accelerated bioactivation of CC1(4) to the toxic trichloromethyl free radical.Entities:
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Year: 1982 PMID： 7089997 DOI： 10.1016/0378-4274(82)90241-7
Source DB: PubMed Journal: Toxicol Lett ISSN： 0378-4274 Impact factor: 4.372