Literature DB >> 6418782

Effect of CO2-induced hyperventilation on carbon tetrachloride (CCl4) levels following acute CCl4 poisoning.

J Gellert, L Goldermann, R Teschke.   

Abstract

To study under standardized experimental conditions the effect of a CO2-induced hyperventilation therapy on carbon tetrachloride (CCl4) levels following acute CCl4 poisoning, rats received 2.5 ml CCl4/kg BW by gastric intubation and were subsequently either treated by CO2-induced hyperventilation or kept in an atmosphere containing air. Peak levels of CCl4 were observed in the fat, liver and blood 3-6 h after the intoxication and were found to be considerably lower in animals treated by CO2-induced hyperventilation compared to their respective controls. These data therefore strongly support the efficacy of the CO2-induced hyperventilation therapy for CCl4 intoxication.

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Year:  1983        PMID： 6418782     DOI： 10.1007/BF01692552

Source DB:  PubMed          Journal:  Intensive Care Med        ISSN： 0342-4642            Impact factor:   17.440


  31 in total

1.  Acute renal failure associated with carbon tetrachloride intoxication.

Authors:  P S NEW; G D LUBASH; L SCHERR; A L RUBIN
Journal:  JAMA       Date:  1962-09-08       Impact factor: 56.272

2.  The pathology of fatal carbon tetrachloride poisoning with special reference to the histogenesis of the hepatic and renal lesions.

Authors:  H D MOON
Journal:  Am J Pathol       Date:  1950-11       Impact factor: 4.307

3.  The effect of mild hypothermia in CCl4 toxic hepatitis (histologic and functional study).

Authors:  S C Bartsokas; D G Papadimitriou; N X Papacharalampous; D Varonos
Journal:  Acta Hepatogastroenterol (Stuttg)       Date:  1973 Jul-Aug

4.  Treatment of carbon tetrachloride poisoning with hyperbaric oxygen.

Authors:  C D Truss; P G Killenberg
Journal:  Gastroenterology       Date:  1982-04       Impact factor: 22.682

5.  Fasting accelerates the in vivo metabolism of carbon tetrachloride in rats.

Authors:  C P Siegers; O Strubelt; E Dost-Kempf
Journal:  Toxicol Lett       Date:  1982-03       Impact factor: 4.372

6.  Acute carbon tetrachloride poisoning.

Authors:  S F Hadi; N El Mikatti
Journal:  Intensive Care Med       Date:  1981       Impact factor: 17.440

7.  Reactivity and toxicity among halogenated methanes and related compounds. A physicochemical correlate with predictive value.

Authors:  R P Hanzlik
Journal:  Biochem Pharmacol       Date:  1981-11-15       Impact factor: 5.858

8.  A new concept of therapy in accidental intoxications with halogenated hydrocarbons.

Authors:  P Lemburg; I Sprock; A Bretschneider; W Storm; U Göbel
Journal:  Vet Hum Toxicol       Date:  1979

Review 9.  [Therapy of acute exogenous intoxications using hemo- and peritoneal dialysis and results of this treatment in GDR in the years 1959-1968].

Authors:  H Dutz; D Eckardt; L Lachhein; P Althaus; W Gerhardt; W Houda; K Jungmann; W Kallas; L Klimpel; H Klinkmann; E Lemke; D Müller; U Otto; K Precht; E Rohmann; H Thieler; H J Tredt; K Zenker
Journal:  Dtsch Gesundheitsw       Date:  1970-07-31

10.  Protective effect of CO2-induced hyperventilation on the hepatotoxicity elicited by carbon tetrachloride.

Authors:  H Frenzel; T Heidenreich; J Gellert; R Teschke
Journal:  Liver       Date:  1982-12
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  2 in total

1.  Effect of ethanol on carbon tetrachloride levels and hepatotoxicity after acute carbon tetrachloride poisoning.

Authors:  R Teschke; W Vierke; J Gellert
Journal:  Arch Toxicol       Date:  1984-12       Impact factor: 5.153

Review 2.  Liver Injury by Carbon Tetrachloride Intoxication in 16 Patients Treated with Forced Ventilation to Accelerate Toxin Removal via the Lungs: A Clinical Report.

Authors:  Rolf Teschke
Journal:  Toxics       Date:  2018-04-27
  2 in total

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