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Literature DB >> 7089531

Reduced leucine-enkephalin--like immunoreactive substance in hamster basal ganglia after long-term ethanol exposure.

K Blum, A H Briggs, S F Elston, L DeLallo, P J Sheridan, M Sar.

Abstract

Golden Syrian hamsters were placed individually in cages with three drinking bottles--one empty, one containing water, and the third containing water and ethanol. Control hamsters received water only. After 1 year the experimental hamsters showed a significantly lower concentration of leucine-enkephalin-like immunoreactive substance in the basal ganglia than the control hamsters. This finding indicates that the action of ethanol involves endogenous peptidyl opiates.

Entities: Chemical Disease Species

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Year: 1982 PMID： 7089531 DOI： 10.1126/science.7089531

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

16 in total

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5. Wernicke-Korsakoff encephalopathy and the endorphin system.

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Authors: W A Banks; A J Kastin
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Reduced leucine-enkephalin--like immunoreactive substance in hamster basal ganglia after long-term ethanol exposure.

Review 1. The complexity of alcohol drinking: studies in rodent genetic models.

Review 2. Sex, drugs, and rock 'n' roll: hypothesizing common mesolimbic activation as a function of reward gene polymorphisms.

3. Fifty Years in the Development of a Glutaminergic-Dopaminergic Optimization Complex (KB220) to Balance Brain Reward Circuitry in Reward Deficiency Syndrome: A Pictorial.

4. Hypothesizing That Neuropharmacological and Neuroimaging Studies of Glutaminergic-Dopaminergic Optimization Complex (KB220Z) Are Associated With "Dopamine Homeostasis" in Reward Deficiency Syndrome (RDS).

5. Wernicke-Korsakoff encephalopathy and the endorphin system.

6. Effect of neurotransmitters on the system that transports Tyr-MIF-1 and the enkephalins across the blood-brain barrier: a dominant role for serotonin.

Review 7. Ethanol ingestive behavior as a function of central neurotransmission.

Review 8. Endogenous opioids and excessive alcohol consumption.

9. Neurogenetics and Epigenetics in Impulsive Behaviour: Impact on Reward Circuitry.

Review 10. The effect of ethanol on the biosynthesis and regulation of opioid peptides.