Literature DB >> 7084417

Structure elucidation of mammalian TCDD-metabolites.

H Poiger, H R Buser, H Weber, U Zweifel, C Schlatter.   

Abstract

Thin layer and gas chromatographic examination of the bile of dogs which were given tritium-labelled TCDD revealed the presence of several polar biotransformation products. The structure of 5 phenolic metabolites was elucidated by combined gas chromatography-mass spectrometry. A metabolic breakdown scheme for TCDD in the dog is proposed.

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Year:  1982        PMID： 7084417     DOI： 10.1007/BF01952652

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

1.  Arene oxides and the NIH shift: the metabolism, toxicity and carcinogenicity of aromatic compounds.

Authors:  J W Daly; D M Jerina; B Witkop
Journal:  Experientia       Date:  1972-10-15

2.  Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the golden Syrian hamster.

Authors:  J R Olson; M A Holscher; R A Neal
Journal:  Toxicol Appl Pharmacol       Date:  1980-08       Impact factor: 4.219

3.  Tissue distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the Golden Syrian hamster.

Authors:  J R Olson; T A Gasiewicz; R A Neal
Journal:  Toxicol Appl Pharmacol       Date:  1980-10       Impact factor: 4.219

4.  Identification of hydroxylated chlorodibenzo-p-dioxins, chlorodibenzofurans, chlorodiphenyl ethers and chloronaphthalenes as their methyl ethers by gas chromatography mass spectrometry.

Authors:  M T Tulp; O Hutzinger
Journal:  Biomed Mass Spectrom       Date:  1978-03

5.  Biological degradation of TCDD in rats.

Authors:  H Poiger; C Schlatter
Journal:  Nature       Date:  1979-10-25       Impact factor: 49.962

6.  Studies on the bioaccumulation and microbial degradation of 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Authors:  F Matsumura; H J Benezet
Journal:  Environ Health Perspect       Date:  1973-09       Impact factor: 9.031

7.  Toxicology of chlorinated dibenzo-p-dioxins.

Authors:  B A Schwetz; J M Norris; G L Sparschu; U K Rowe; P J Gehring; J L Emerson; C G Gerbig
Journal:  Environ Health Perspect       Date:  1973-09       Impact factor: 9.031
  7 in total
  6 in total

1.  A microbial metabolite of TCDD.

Authors:  M Philippi; J Schmid; H K Wipf; R Hütter
Journal:  Experientia       Date:  1982-06-15

2.  The involvement of CYP1A2 in biodegradation of dioxins in pigs.

Authors:  Sylwia Swigonska; Tomasz Molcan; Anna Nynca; Renata E Ciereszko
Journal:  PLoS One       Date:  2022-05-26       Impact factor: 3.752

3.  Influence of phenobarbital and TCDD on the hepatic metabolism of TCDD in the dog.

Authors:  H Poiger; C Schlatter
Journal:  Experientia       Date:  1985-03-15

Review 4.  The role of structure in the disposition of halogenated aromatic xenobiotics.

Authors:  L S Birnbaum
Journal:  Environ Health Perspect       Date:  1985-09       Impact factor: 9.031

Review 5.  Mammalian cytochrome P450-dependent metabolism of polychlorinated dibenzo-p-dioxins and coplanar polychlorinated biphenyls.

Authors:  Hideyuki Inui; Toshimasa Itoh; Keiko Yamamoto; Shin-Ichi Ikushiro; Toshiyuki Sakaki
Journal:  Int J Mol Sci       Date:  2014-08-13       Impact factor: 5.923

6.  Analysis of polychlorinated dibenzofurans, dioxins and related compounds in environmental samples.

Authors:  H R Buser; C Rappe; P A Bergqvist
Journal:  Environ Health Perspect       Date:  1985-05       Impact factor: 9.031
  6 in total

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